HitPredict

Interactor 1: WNT3A (P27467)
Protein Wnt-3a
Gene: WNT3A

Interactor 2: SFRP4 (Q9Z1N6)
Secreted frizzled-related sequence protein 4 (FRP-4) (sFRP-4)
Gene: SFRP4

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	17462603
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Fz~wnt
Common GO terms	GO:0005615 - extracellular space GO:0035567 - non-canonical Wnt signaling pathway GO:0060070 - canonical Wnt signaling pathway GO:0090263 - positive regulation of canonical Wnt signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 352 Mm			1 351
+	Mm
		648271 WNT3A_MOUSE (1-352): 0: 521: 100.00		SFRP3_MOUSE (18-329): 6.46e-123: 358: 51.75
+	Mm
		648270 WNT3A_MOUSE (1-352): 0: 521: 100.00		SFRP2_MOUSE (20-292): 6.69e-82: 252: 21.35
+	Mm
		648274 WNT3A_MOUSE (1-352): 0: 521: 100.00		SFRP1_MOUSE (26-295): 6.23e-78: 243: 21.38
+	Hs
		881854 WNT3A_HUMAN (1-352): 0: 520: 96.02		FZD5_HUMAN (11-211): 3.2e-69: 228: 34.15
+	Gg
		1101462 WNT3A_CHICK (1-352): 0: 522: 88.07		FZD10_CHICK (1-179): 1.87e-65: 218: 29.08
+	Mm
		648273 WNT3A_MOUSE (1-352): 0: 521: 100.00		FZD8_MOUSE (2-146): 3.57e-59: 203: 37.58
+	Hs
		881855 WNT3A_HUMAN (1-352): 0: 520: 96.02		FZD2_HUMAN (19-157): 5.34e-58: 198: 38.57
+	Hs
		881870 WNT3A_HUMAN (1-352): 0: 520: 96.02		FZD1_HUMAN (19-154): 1.13e-56: 196: 38.69
+	Xl
		679053 WNT3A_XENLA (1-352): 0: 516: 84.66		FZD7A_XENLA (19-162): 1.09e-57: 197: 39.31
+	Hs
		254158 WNT3_HUMAN (15-352): 9.46e-179: 501: 85.80		FZD7_HUMAN (19-175): 5.5e-57: 196: 36.20
+	Hs
		881890 WNT4_HUMAN (8-352): 3.52e-148: 423: 47.13		SFRP2_HUMAN (20-292): 5.54e-84: 258: 21.35
+	Mm
		611177 WNT5A_MOUSE (7-352): 3.25e-153: 437: 44.04		SFRP1_MOUSE (26-295): 6.23e-78: 243: 21.38
+	Hs
		881885 WNT4_HUMAN (8-352): 3.52e-148: 423: 47.13		SFRP1_HUMAN (26-295): 1.26e-70: 224: 20.29
+	Gg
		1265021 WNT1_CHICK (12-351): 1.66e-148: 425: 45.69		FZD10_CHICK (1-179): 1.87e-65: 218: 29.08
+	Hs
		782082 WNT5A_HUMAN (7-352): 9.57e-154: 438: 44.04		FZD2_HUMAN (19-157): 5.34e-58: 198: 38.57
+	Hs
		782105 WNT5A_HUMAN (7-352): 9.57e-154: 438: 44.04		FZD1_HUMAN (19-154): 1.13e-56: 196: 38.69
+	Mm
		611174 WNT5A_MOUSE (7-352): 3.25e-153: 437: 44.04		FZD4_MOUSE (23-196): 1.28e-56: 194: 27.27
+	Mm
		656029 WNT7B_MOUSE (26-352): 6.67e-148: 422: 45.59		FZD10_MOUSE (9-180): 1.04e-60: 206: 31.25
+	Mm
		250808 WNT7B_MOUSE (26-352): 6.67e-148: 422: 45.59		FZD1_MOUSE (19-154): 2.31e-56: 195: 38.69
+	Mm
		656028 WNT7B_MOUSE (26-352): 6.67e-148: 422: 45.59		FZD4_MOUSE (23-196): 1.28e-56: 194: 27.27