Protein: ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Alkaline phosphodiesterase I) (EC 3.1.4.1) (Membrane component chromosome 6 surface marker 1) (Nucleotide diphosphatase) (Nucleotide pyrophosphatase) (NPPase) (EC 3.6.1.9) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form]

Gene: ENPP1
Organism: Homo sapiens
Interactions: 83
UniProt ID: P22413

Gene Ontology (top 5):
GO:0003676 - nucleic acid binding
GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004527 - exonuclease activity
GO:0004528 - phosphodiesterase I activity
GO:0004551 - dinucleotide phosphatase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

648277

PTC1
Protein patched homolog 1

3

2

High-throughput

0.667

High

648266

FNTB
Protein farnesyltransferase subunit beta

3

0

High-throughput

0.638

High

648287

5MP2
eIF5-mimic protein 2

3

0

High-throughput

0.638

High

439639

INSR
Insulin receptor

2

1

Small-scale

0.624

High

648312

FANCE
Fanconi anemia group E protein

2

0

High-throughput

0.602

High

170659

CLGN
Calmegin

2

8

High-throughput

0.601

High

480701

LEG1
Galectin-1

2

4

High-throughput

0.601

High

648272

CD81
CD81 antigen

2

2

Small-scale

0.601

High

648274

VA0D1
V-type proton ATPase subunit d 1

2

0

High-throughput

0.585

High

648279

PON2
Serum paraoxonase/arylesterase 2

2

0

High-throughput

0.585

High

648322

ABCG2
Broad substrate specificity ATP-binding cassette transporter ABCG2

1

0

Small-scale

0.554

High

648304

SAAL1
Protein SAAL1

2

1

High-throughput

0.549

High

648321

FBX2
F-box only protein 2

2

4

High-throughput

0.549

High

648261

CALX
Calnexin

1

8

High-throughput

0.536

High

648267

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

High-throughput

0.536

High

648276

SQSTM
Sequestosome-1

1

1

High-throughput

0.536

High

648302

T106A
Transmembrane protein 106A

1

4

High-throughput

0.536

High

648308

C1QT7
Complement C1q tumor necrosis factor-related protein 7

1

1

High-throughput

0.536

High

344394

TBCD8
TBC1 domain family member 8

1

0

High-throughput

0.513

High

593274

PGFRA
Platelet-derived growth factor receptor alpha

1

0

High-throughput

0.513

High

648268

GPC3
Glypican-3

1

0

High-throughput

0.513

High

648271

DEF1
Neutrophil defensin 1

1

0

High-throughput

0.513

High

648280

INSC
Protein inscuteable homolog

1

0

High-throughput

0.513

High

648311

SMYD3
Histone-lysine N-methyltransferase SMYD3

1

0

High-throughput

0.513

High

648315

STK36
Serine/threonine-protein kinase 36

1

0

High-throughput

0.513

High

288350

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

1

Small-scale

0.501

High

388606

C1QA
Complement C1q subcomponent subunit A

1

1

High-throughput

0.489

High

648281

CL12B
C-type lectin domain family 12 member B

1

4

High-throughput

0.489

High

125232

LEG9
Galectin-9

1

4

High-throughput

0.479

High

217833

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

256769

H2B1K
Histone H2B type 1-K

1

2

High-throughput

0.479

High

293200

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

648270

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.479

High

648273

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

648303

LRC59
Leucine-rich repeat-containing protein 59

1

3

High-throughput

0.479

High

648310

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

648316

T106B
Transmembrane protein 106B

1

4

High-throughput

0.479

High

128145

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

Small-scale

0.458

High

342748

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

536234

PPAL
Lysosomal acid phosphatase

1

0

High-throughput

0.458

High

648318

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

648319

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

67071

S38A8
Solute carrier family 38 member 8

1

1

High-throughput

0.445

High

255980

S19A2
Thiamine transporter 1

1

2

High-throughput

0.445

High

648262

CTR1
High affinity cationic amino acid transporter 1

1

4

High-throughput

0.445

High

648263

MOT8
Monocarboxylate transporter 8

1

5

High-throughput

0.445

High

648265

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

1

High-throughput

0.445

High

648269

CTR2
Cationic amino acid transporter 2

1

4

High-throughput

0.445

High

648278

S39AE
Metal cation symporter ZIP14

1

9

High-throughput

0.445

High

648282

S35G1
Solute carrier family 35 member G1

1

2

High-throughput

0.445

High

648283

S39AC
Zinc transporter ZIP12

1

9

High-throughput

0.445

High

648284

MFSD5
Molybdate-anion transporter

1

3

High-throughput

0.445

High

648286

S39A4
Zinc transporter ZIP4

1

9

High-throughput

0.445

High

648288

NIPA1
Magnesium transporter NIPA1

1

2

High-throughput

0.445

High

648290

S22A9
Organic anion transporter 7

1

3

High-throughput

0.445

High

648291

S35F2
Solute carrier family 35 member F2

1

1

High-throughput

0.445

High

648293

S39AB
Zinc transporter ZIP11

1

9

High-throughput

0.445

High

648295

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

5

High-throughput

0.445

High

648296

S7A14
Solute carrier family 7 member 14

1

4

High-throughput

0.445

High

648298

CTR3
Cationic amino acid transporter 3

1

4

High-throughput

0.445

High

648299

S39A7
Zinc transporter SLC39A7

1

9

High-throughput

0.445

High

648300

YLAT2
Y+L amino acid transporter 2

1

4

High-throughput

0.445

High

648305

S39AD
Zinc transporter ZIP13

1

9

High-throughput

0.445

High

648309

S39A8
Metal cation symporter ZIP8

1

9

High-throughput

0.445

High

648313

ANKH
Mineralization regulator ANKH

1

1

High-throughput

0.445

High

648317

S39A1
Zinc transporter ZIP1

1

9

High-throughput

0.445

High

648301

H2B1H
Histone H2B type 1-H

1

2

High-throughput

0.437

High

648307

CALR3
Calreticulin-3

1

8

High-throughput

0.437

High

648314

FBX6
F-box only protein 6

1

4

High-throughput

0.437

High

65407

MFS2B
Sphingosine-1-phosphate transporter MFSD2B

1

0

High-throughput

0.426

High

648289

SL9B2
Sodium/hydrogen exchanger 9B2

1

0

High-throughput

0.426

High

648292

S35F3
Solute carrier family 35 member F3

1

0

High-throughput

0.426

High

648294

TOIP2
Torsin-1A-interacting protein 2

1

0

High-throughput

0.426

High

648324

FLVC1
Choline/ethanolamine transporter FLVCR1

1

0

High-throughput

0.426

High

648297

TBC15
TBC1 domain family member 15

1

1

High-throughput

0.407

High

648275

LCN6
Epididymal-specific lipocalin-6

1

0

High-throughput

0.279

Low

648285

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.279

Low

648306

LCFC1
Sperm-egg fusion protein LLCFC1

1

0

High-throughput

0.279

Low

633594

PSB1
Proteasome subunit beta type-1

1

0

Small-scale

0.249

Low

648260

PSA1
Proteasome subunit alpha type-1

1

0

Small-scale

0.249

Low

648264

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

648320

XPO7
Exportin-7

1

0

High-throughput

0.249

Low

648323

S35A3
UDP-N-acetylglucosamine transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025