HitPredict

Interactor 1: ARNT (P27540)
Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta)
Gene: ARNT

Interactor 2: HIF3A (Q9Y2N7)
Hypoxia-inducible factor 3-alpha (HIF-3-alpha) (HIF3-alpha) (Basic-helix-loop-helix-PAS protein MOP7) (Class E basic helix-loop-helix protein 17) (bHLHe17) (HIF3-alpha-1) (Inhibitory PAS domain protein) (IPAS) (Member of PAS protein 7) (PAS domain-containing protein 7)
Gene: HIF3A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.855

Property	Details
Experiments	16126907, 16182248, 26160453
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	HLH~PAS, PAS~PAS, PAS~PAS_11, PAS_11~PAS_11
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 789 Hs			1 669
+	Hs
		649106 ARNT_HUMAN (1-789): 0: 649: 100.00		SIM2_HUMAN (16-666): 1.85e-151: 455: 26.46
+	Hs
		649084 ARNT_HUMAN (1-789): 0: 649: 100.00		SIM1_HUMAN (16-659): 3.47e-146: 445: 26.05
+	Hs
		649123 ARNT_HUMAN (1-789): 0: 649: 100.00		HIF1A_HUMAN (6-651): 9.51e-145: 443: 34.01
+	Hs
		649150 ARNT_HUMAN (1-789): 0: 649: 100.00		EPAS1_HUMAN (1-663): 3.7e-143: 440: 34.83
+	Mm
		864792 ARNT_MOUSE (1-789): 0: 637: 91.40		SIM1_MOUSE (16-659): 1.49e-146: 446: 25.79
+	Mm
		864794 ARNT_MOUSE (1-789): 0: 637: 91.40		HIF1A_MOUSE (6-662): 1.74e-145: 445: 32.63
+	Mm
		864793 ARNT_MOUSE (1-789): 0: 637: 91.40		SIM2_MOUSE (16-666): 5.33e-143: 433: 26.61
+	Mm
		864790 ARNT_MOUSE (1-789): 0: 637: 91.40		EPAS1_MOUSE (1-669): 6.86e-137: 424: 34.53
+	Hs
		649033 ARNT_HUMAN (1-789): 0: 649: 100.00		ARNT_HUMAN (4-604): 2.12e-126: 394: 18.64
+	Hs
		649132 ARNT_HUMAN (1-789): 0: 649: 100.00		NPAS3_HUMAN (9-660): 1.65e-124: 393: 23.25
+	Mm
		101520 ARNT_MOUSE (1-789): 0: 637: 91.40		F8VQB2_MOUSE (9-659): 4.62e-125: 395: 23.24
+	Hs
		649117 ARNT_HUMAN (1-789): 0: 649: 100.00		NCOA2_HUMAN (5-638): 8.85e-116: 380: 18.53
+	Hs
		181499 ARNT_HUMAN (1-789): 0: 649: 100.00		CLOCK_HUMAN (4-668): 7.71e-120: 379: 16.03
+	Hs
		649131 ARNT_HUMAN (1-789): 0: 649: 100.00		NPAS4_HUMAN (17-609): 6.1e-115: 365: 23.48
+	Hs
		649052 ARNT_HUMAN (1-789): 0: 649: 100.00		AHR_HUMAN (3-661): 2.9e-112: 359: 17.47
+	Mm
		864796 ARNT_MOUSE (1-789): 0: 637: 91.40		NPAS4_MOUSE (17-609): 2.83e-111: 355: 23.16
+	Hs
		649148 ARNT_HUMAN (1-789): 0: 649: 100.00		NPAS1_HUMAN (12-464): 5e-104: 330: 27.36
+	Mm
		674910 ARNT_MOUSE (1-789): 0: 637: 91.40		AHR_MOUSE (3-669): 3.68e-101: 330: 18.30
+	Hs
		649149 ARNT_HUMAN (1-789): 0: 649: 100.00		NPAS2_HUMAN (6-668): 1.47e-96: 317: 17.02
+	Mm
		864789 ARNT_MOUSE (1-789): 0: 637: 91.40		NPAS1_MOUSE (12-464): 6.43e-103: 327: 27.15