HitPredict

Interactor 1: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Interactor 2: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Gene: MTOR

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37827155
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response GO:0016605 - PML body
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 616 Hs			1 2549
+	Hs
		651111 RFA1_HUMAN (1-616): 0: 781: 100.00		ATM_HUMAN (387-2548): 0: 894: 14.98
+	Hs
		651136 RFA1_HUMAN (1-616): 0: 781: 100.00		ATR_HUMAN (186-2548): 0: 816: 14.82
+	Hs
		652700 RFA1_HUMAN (1-616): 0: 781: 100.00		TRRAP_HUMAN (925-2548): 0: 720: 15.53
+	Hs
		650943 RFA1_HUMAN (1-616): 0: 781: 100.00		PRKDC_HUMAN (695-2548): 0: 686: 14.83
+	Sc
		607270 RFA1_YEAST (4-615): 0: 596: 31.69		TRA1_YEAST (202-2549): 0: 657: 12.49
+	Sc
		607258 RFA1_YEAST (4-615): 0: 596: 31.69		ATM_YEAST (1223-2549): 6.86e-154: 538: 15.87
+	Hs
		651835 RFA1_HUMAN (1-616): 0: 781: 100.00		GCN1_HUMAN (245-1372): 1.05e-38: 162: 12.17
+	Sc
		607246 RFA1_YEAST (4-615): 0: 596: 31.69		GCN1_YEAST (666-1247): 2.46e-13: 78.5: 14.26
+	Sc
		607259 RFA1_YEAST (4-615): 0: 596: 31.69		ATR_YEAST (2477-2549): 3.41e-11: 71.7: 31.51