Protein: NAP1
Nucleosome assembly protein

Gene: NAP1
Organism: Saccharomyces cerevisiae S288C
Interactions: 216
UniProt ID: P25293

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000920 - septum digestion after cytokinesis
GO:0000921 - septin ring assembly
GO:0003677 - DNA binding
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

419363

H2A1
Histone H2A.1

16

14

Small-scale

0.984

High

670368

H2AZ
Histone H2A.Z

15

19

Small-scale

0.981

High

419613

H2A2
Histone H2A.2

13

14

Small-scale

0.978

High

670213

NAP1
Nucleosome assembly protein

9

15

Small-scale

0.975

High

381414

H2B2
Histone H2B.2

9

20

Small-scale

0.968

High

380981

H2B1
Histone H2B.1

9

19

Small-scale

0.968

High

670320

H3
Histone H3

4

19

Small-scale

0.875

High

670360

GIN4
Serine/threonine-protein kinase GIN4

13

3

Small-scale

0.761

High

670299

IMB5
Importin subunit beta-5

10

3

Small-scale

0.758

High

670217

KCC4
Probable serine/threonine-protein kinase KCC4

10

3

Small-scale

0.755

High

670258

RIM11
Serine/threonine-protein kinase RIM11/MSD1

7

9

High-throughput

0.748

High

670309

SDA1
Protein SDA1

7

3

Small-scale

0.746

High

670317

NIS1
Protein NIS1

9

0

Small-scale

0.724

High

670345

RT109
Histone acetyltransferase RTT109

1

0

Small-scale

0.722

High

670346

NBA1
Protein NBA1

6

0

Small-scale

0.702

High

670243

HSL1
Probable serine/threonine-protein kinase HSL1

4

3

High-throughput

0.690

High

670356

YRA1
RNA annealing protein YRA1

5

0

Small-scale

0.684

High

633212

KICH
Choline kinase

4

1

Small-scale

0.681

High

667068

CG22
G2/mitotic-specific cyclin-2

3

2

Small-scale

0.674

High

670257

REI1
Cytoplasmic 60S subunit biogenesis factor REI1

4

0

High-throughput

0.668

High

670357

NBP2
NAP1-binding protein 2

4

0

Small-scale

0.658

High

510226

HSP77
Import motor subunit, mitochondrial

3

7

Small-scale

0.656

High

670369

AIM44
Altered inheritance of mitochondria protein 44

3

0

Small-scale

0.649

High

578900

HSC82
ATP-dependent molecular chaperone HSC82

3

1

Small-scale

0.640

High

670355

YP150
Putative serine/threonine-protein kinase YPL150W

4

1

High-throughput

0.636

High

670275

SSB2
Ribosome-associated molecular chaperone SSB2

3

7

High-throughput

0.634

High

523142

HSP71
Heat shock protein SSA1

3

7

Small-scale

0.624

High

525989

HSP72
Heat shock protein SSA2

3

7

Small-scale

0.624

High

543909

SSB1
Ribosome-associated molecular chaperone SSB1

3

7

Small-scale

0.624

High

670229

ATS1
Protein KTI13

2

2

Small-scale

0.620

High

574642

KSS1
Mitogen-activated protein kinase KSS1

2

3

High-throughput

0.619

High

670248

CENPA
Histone H3-like centromeric protein CSE4

1

19

High-throughput

0.618

High

670306

CDH1
APC/C activator protein CDH1

2

7

Small-scale

0.611

High

670323

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

2

1

High-throughput

0.611

High

670330

GCN5
Histone acetyltransferase GCN5

2

13

High-throughput

0.601

High

414992

RL39
Large ribosomal subunit protein eL39

2

5

High-throughput

0.595

High

670288

MPG1
Mannose-1-phosphate guanyltransferase

2

1

High-throughput

0.588

High

381891

H4
Histone H4

2

5

Small-scale

0.584

High

670218

RS2
Small ribosomal subunit protein uS5

2

1

Small-scale

0.584

High

670234

CDC11
Cell division control protein 11

2

2

High-throughput

0.576

High

670302

MLC1
Myosin light chain 1

2

1

High-throughput

0.576

High

670342

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

2

0

High-throughput

0.576

High

623775

MYO2
Myosin-2

2

3

High-throughput

0.571

High

670214

SIS1
Protein SIS1

2

2

High-throughput

0.571

High

670216

CDC10
Cell division control protein 10

2

1

High-throughput

0.571

High

670226

TF2B
Transcription initiation factor IIB

2

0

Small-scale

0.569

High

512275

RS6A
Small ribosomal subunit protein eS6A

2

4

High-throughput

0.566

High

670260

RS20
Small ribosomal subunit protein uS10

2

0

Small-scale

0.559

High

670237

HSP7F
Heat shock protein homolog SSE1

2

9

High-throughput

0.552

High

643203

FNTB
Protein farnesyltransferase subunit beta

2

1

High-throughput

0.548

High

670316

BNI5
Bud neck protein 5

2

0

High-throughput

0.547

High

670222

SRO9
RNA-binding protein SRO9

1

3

High-throughput

0.541

High

670228

XPO1
Exportin-1

1

5

High-throughput

0.536

High

670311

PAP2
Poly(A) RNA polymerase protein 2

1

1

High-throughput

0.536

High

511541

RL44B
Large ribosomal subunit protein eL42B

2

6

High-throughput

0.535

High

464558

PBS2
MAP kinase kinase PBS2

1

4

High-throughput

0.515

High

561422

TBP
TATA-box-binding protein

1

1

High-throughput

0.515

High

670236

SPT16
FACT complex subunit SPT16

1

1

High-throughput

0.515

High

670241

CNS1
Hsp70/Hsp90 co-chaperone CNS1

1

2

High-throughput

0.515

High

670281

YRB2
Ran-specific GTPase-activating protein 2

1

2

High-throughput

0.515

High

670335

HFD1
Fatty aldehyde dehydrogenase HFD1

1

1

High-throughput

0.515

High

670336

POB3
FACT complex subunit POB3

1

1

High-throughput

0.515

High

670354

CHS5
Chitin biosynthesis protein CHS5

1

1

High-throughput

0.515

High

448137

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.513

High

558597

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.513

High

670220

SGF29
SAGA complex subunit SGF29

1

0

High-throughput

0.513

High

670225

YJU2
Splicing factor YJU2

1

0

High-throughput

0.513

High

670298

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

0

High-throughput

0.513

High

670303

SGF73
SAGA complex subunit SGF73

1

0

High-throughput

0.513

High

670310

BUD32
EKC/KEOPS complex subunit BUD32

1

0

High-throughput

0.513

High

670328

HOT1
High-osmolarity-induced transcription protein 1

1

0

High-throughput

0.513

High

670365

PCL9
PHO85 cyclin-9

1

0

High-throughput

0.513

High

670287

YRB1
Ran-specific GTPase-activating protein 1

1

2

High-throughput

0.508

High

670363

HMS1
Probable transcription factor HMS1

1

3

High-throughput

0.508

High

441046

KAPA
cAMP-dependent protein kinase type 1

1

2

High-throughput

0.501

High

517907

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.501

High

602329

PHO85
Cyclin-dependent protein kinase PHO85

1

3

High-throughput

0.501

High

656373

KC11
Casein kinase I homolog 1

1

1

High-throughput

0.501

High

670259

RCK1
Serine/threonine-protein kinase RCK1

1

2

High-throughput

0.501

High

670266

AURK
Aurora kinase

1

5

High-throughput

0.501

High

670285

BNI1
Protein BNI1

1

1

High-throughput

0.501

High

670301

ATG1
Serine/threonine-protein kinase ATG1

1

2

High-throughput

0.501

High

670327

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

1

High-throughput

0.501

High

670331

ENT5
Epsin-5

1

1

Small-scale

0.501

High

670348

ESA1
Histone acetyltransferase ESA1

1

7

Small-scale

0.501

High

670231

P5CR
Pyrroline-5-carboxylate reductase

1

0

High-throughput

0.493

High

670239

GYP6
GTPase-activating protein GYP6

1

0

High-throughput

0.493

High

670249

RNZ
Ribonuclease Z

1

0

High-throughput

0.493

High

670254

SLT11
Pre-mRNA-splicing factor SLT11

1

0

High-throughput

0.493

High

670274

THO1
Protein THO1

1

0

High-throughput

0.493

High

670294

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

High-throughput

0.493

High

670304

DUO1
DASH complex subunit DUO1

1

0

High-throughput

0.493

High

670308

PESC
Pescadillo homolog

1

0

High-throughput

0.493

High

670325

YKZ1
Uncharacterized protein YKR011C

1

0

High-throughput

0.493

High

670361

WTM1
Transcriptional modulator WTM1

1

0

High-throughput

0.493

High

670367

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

1

High-throughput

0.489

High

670286

GPD2
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, mitochondrial

1

0

High-throughput

0.486

High

670246

PP2C1
Protein phosphatase 2C homolog 1

1

1

High-throughput

0.481

High

149604

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.479

High

392280

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

394264

EF1A
Elongation factor 1-alpha

1

2

Small-scale

0.479

High

435790

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

454895

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

622876

CSK22
Casein kinase II subunit alpha'

1

20

Small-scale

0.479

High

670224

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

670247

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

670250

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

1

Small-scale

0.479

High

670253

ATG8
Autophagy-related protein 8

1

6

High-throughput

0.479

High

670256

ENP1
Essential nuclear protein 1

1

2

High-throughput

0.479

High

670290

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

2

High-throughput

0.479

High

670312

HST2
NAD-dependent protein deacetylase HST2

1

4

High-throughput

0.479

High

670318

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.479

High

670324

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

670329

TOM1
E3 ubiquitin-protein ligase TOM1

1

6

High-throughput

0.479

High

670333

SXM1
Importin beta SMX1

1

5

Small-scale

0.479

High

670334

SIZ1
E3 SUMO-protein ligase SIZ1

1

1

High-throughput

0.479

High

670359

SIZ2
E3 SUMO-protein ligase SIZ2

1

1

High-throughput

0.479

High

670364

CEX1
Cytoplasmic export protein 1

1

2

High-throughput

0.479

High

670366

CMR1
DNA damage-binding protein CMR1

1

3

High-throughput

0.479

High

456506

ARD1
N-terminal acetyltransferase A complex catalytic subunit ARD1

1

2

High-throughput

0.470

High

670339

CORO
Coronin-like protein

1

1

High-throughput

0.470

High

670300

APC10
Anaphase-promoting complex subunit DOC1

1

2

High-throughput

0.464

High

557669

SRS2
ATP-dependent DNA helicase SRS2

1

0

Small-scale

0.460

High

670273

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.460

High

434851

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

594209

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

Small-scale

0.458

High

603016

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

647015

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

649567

KCC2
Calcium/calmodulin-dependent protein kinase II

1

0

High-throughput

0.458

High

670230

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

670251

AKL1
Serine/threonine-protein kinase AKL1

1

0

High-throughput

0.458

High

670252

NU170
Nucleoporin NUP170

1

0

High-throughput

0.458

High

670264

RIX1
Pre-rRNA-processing protein RIX1

1

0

High-throughput

0.458

High

670267

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

670277

SIP5
Protein SIP5

1

0

Small-scale

0.458

High

670282

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

670295

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

670314

FOL1
Folic acid synthesis protein FOL1 [Includes: Dihydroneopterin aldolase

1

0

Small-scale

0.458

High

670326

SHR3
Secretory component protein SHR3

1

0

High-throughput

0.458

High

670337

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

670338

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

670340

LOA1
Lysophosphatidic acid:oleoyl-CoA acyltransferase 1

1

0

High-throughput

0.458

High

670343

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

670347

YNG1
Protein YNG1

1

0

Small-scale

0.458

High

670293

ENT3
Epsin-3

1

1

Small-scale

0.457

High

481494

HSP73
Heat shock protein SSA3

1

7

High-throughput

0.445

High

670215

SWI4
Regulatory protein SWI4

1

1

High-throughput

0.445

High

670219

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.445

High

670238

HSP79
Heat shock protein homolog SSE2

1

9

High-throughput

0.445

High

670244

TOR1
Serine/threonine-protein kinase TOR1

1

1

High-throughput

0.445

High

670245

SPT7
SAGA complex subunit SPT7

1

8

High-throughput

0.445

High

670261

SSZ1
Ribosome-associated complex subunit SSZ1

1

6

High-throughput

0.445

High

670263

KOG1
Target of rapamycin complex 1 subunit KOG1

1

3

High-throughput

0.445

High

670272

HSP7E
Heat shock protein SSC3, mitochondrial

1

7

High-throughput

0.445

High

670283

SAS2
Histone acetyltransferase SAS2

1

6

High-throughput

0.445

High

670313

HST4
NAD-dependent histone deacetylase HST4

1

4

High-throughput

0.445

High

670315

CNM67
Chaotic nuclear migration protein 67

1

3

High-throughput

0.445

High

670319

ACT
Actin

1

3

High-throughput

0.445

High

670322

CDC14
Tyrosine-protein phosphatase CDC14

1

3

High-throughput

0.445

High

670344

SHS1
Seventh homolog of septin 1

1

3

High-throughput

0.445

High

670358

RL7B
Large ribosomal subunit protein uL30B

1

1

High-throughput

0.445

High

657050

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.438

High

670268

PCF11
Protein PCF11

1

0

High-throughput

0.438

High

670284

LYS14
Lysine biosynthesis regulatory protein LYS14

1

0

High-throughput

0.438

High

670332

YAP6
AP-1-like transcription factor YAP6

1

0

High-throughput

0.438

High

409690

RL24A
Large ribosomal subunit protein eL24A

1

3

High-throughput

0.437

High

409951

RL25
Large ribosomal subunit protein uL23

1

4

High-throughput

0.437

High

504052

RL31A
Large ribosomal subunit protein eL31A

1

5

High-throughput

0.437

High

511517

RL44A
Large ribosomal subunit protein eL42A

1

6

High-throughput

0.437

High

512838

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.437

High

513460

RL1A
Large ribosomal subunit protein uL1A

1

2

High-throughput

0.437

High

513954

RL18B
Large ribosomal subunit protein eL18B

1

3

Small-scale

0.437

High

515212

RL35A
Large ribosomal subunit protein uL29A

1

2

High-throughput

0.437

High

585209

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

5

High-throughput

0.437

High

663652

RL24B
Large ribosomal subunit protein eL24B

1

3

High-throughput

0.437

High

670223

SPB4
ATP-dependent rRNA helicase SPB4

1

1

High-throughput

0.437

High

670240

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

670271

RS26A
Small ribosomal subunit protein eS26A

1

2

High-throughput

0.437

High

670321

NUM1
Nuclear migration protein NUM1

1

4

High-throughput

0.437

High

670351

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

453436

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

670227

BMH1
Protein BMH1

1

0

High-throughput

0.426

High

670233

CDC3
Cell division control protein 3

1

0

High-throughput

0.426

High

670235

CDC12
Cell division control protein 12

1

0

High-throughput

0.426

High

670262

CRP1
Cruciform DNA-recognizing protein 1 [Cleaved into: CRP1 short N-terminal subpeptide; CRP1 short C-terminal subpeptide]

1

0

High-throughput

0.426

High

670265

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.426

High

670269

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

670279

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.426

High

670296

SPT20
SAGA complex subunit SPT20

1

0

High-throughput

0.426

High

670353

HFI1
SAGA complex subunit HFI1

1

0

High-throughput

0.426

High

670291

RSSA2
Small ribosomal subunit protein uS2B

1

1

High-throughput

0.407

High

670341

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

3

High-throughput

0.407

High

670350

TCO89
Target of rapamycin complex 1 subunit TCO89

4

0

Small-scale

0.358

High

670242

RS3A1
Small ribosomal subunit protein eS1A

2

0

High-throughput

0.318

High

670297

NBP1
NAP1-binding protein

2

0

Small-scale

0.314

High

670280

LYS12
Homoisocitrate dehydrogenase, mitochondrial

2

0

High-throughput

0.307

High

670307

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.282

High

670255

CS111
F-box protein COS111

1

0

High-throughput

0.279

Low

521110

PRI1
DNA primase small subunit

1

0

High-throughput

0.269

Low

670221

BUD3
Bud site selection protein 3

1

0

High-throughput

0.269

Low

670276

MMF1
Protein MMF1, mitochondrial

1

0

High-throughput

0.269

Low

670352

TGL5
Triacylglycerol lipase 5

1

0

High-throughput

0.269

Low

670232

MSB2
Signaling mucin MSB2

1

0

Small-scale

0.261

Low

670305

PDK2
[Pyruvate dehydrogenase

1

0

High-throughput

0.261

Low

515362

RS32B
Small ribosomal subunit protein eS32B

1

0

High-throughput

0.251

Low

383533

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

441722

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

502866

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

670270

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

670349

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

670362

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.249

Low

515356

RS32A
Small ribosomal subunit protein eS32A

1

0

High-throughput

0.238

Low

670289

ZIM17
Mitochondrial protein import protein ZIM17

1

0

High-throughput

0.238

Low

670278

ELO3
Fatty acid elongase 3

1

0

High-throughput

0.232

Low

670292

STU2
Protein STU2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025