HitPredict

Interactor 1: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Interactor 2: CDK7 (P50613)
Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)
Gene: CDK7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	37827155, 24332808
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 616 Hs			1 346
+	Hs
		625131 RFA1_HUMAN (1-616): 0: 781: 100.00		CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85
+	Hs
		414753 RFA1_HUMAN (1-616): 0: 781: 100.00		CDK1_HUMAN (9-298): 6.62e-135: 387: 43.00
+	Hs
		650972 RFA1_HUMAN (1-616): 0: 781: 100.00		CDK5_HUMAN (9-301): 1.39e-134: 386: 45.09