Protein: ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (EC 3.6.5.-) (G1 to S phase transition protein 2 homolog)

Gene: ERF3B, GSPT2
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q8IYD1

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0003723 - RNA binding
GO:0003747 - translation release factor activity
GO:0003924 - GTPase activity
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

550355

PABP1
Polyadenylate-binding protein 1

7

8

Small-scale

0.974

High

976752

ERF1
Eukaryotic peptide chain release factor subunit 1

5

8

Small-scale

0.930

High

581561

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

5

13

High-throughput

0.927

High

1102016

PABP4
Polyadenylate-binding protein 4

2

8

High-throughput

0.811

High

1314826

RENT1
Regulator of nonsense transcripts 1

4

7

Small-scale

0.710

High

1197172

PAP1L
Polyadenylate-binding protein 1-like

1

8

High-throughput

0.691

High

1314832

ATX2
Ataxin-2

1

3

High-throughput

0.691

High

1314834

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

5

High-throughput

0.691

High

135273

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

2

14

High-throughput

0.628

High

183482

CASC3
Protein CASC3

2

2

High-throughput

0.628

High

462511

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

2

6

High-throughput

0.628

High

889770

CLK3
Dual specificity protein kinase CLK3

2

4

High-throughput

0.628

High

1066710

NCBP1
Nuclear cap-binding protein subunit 1

2

2

High-throughput

0.628

High

1090258

ELAV2
ELAV-like protein 2

2

9

High-throughput

0.628

High

1226023

LAR1B
La-related protein 1B

2

5

High-throughput

0.628

High

1245655

LARP1
La-related protein 1

2

5

High-throughput

0.628

High

1271450

DHX30
ATP-dependent RNA helicase DHX30

2

8

High-throughput

0.628

High

1290583

ZCH18
Zinc finger CCCH domain-containing protein 18

2

5

High-throughput

0.628

High

1314824

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

2

1

High-throughput

0.628

High

1314825

SRS12
Serine/arginine-rich splicing factor 12

2

12

High-throughput

0.628

High

1314829

YTDC1
YTH domain-containing protein 1

2

2

High-throughput

0.628

High

1314838

MOV10
Helicase MOV-10

2

7

High-throughput

0.628

High

1314840

ZCHC3
Zinc finger CCHC domain-containing protein 3

2

2

High-throughput

0.628

High

325923

UBR5
E3 ubiquitin-protein ligase UBR5

1

9

Small-scale

0.618

High

1314847

HDAC6
Protein deacetylase HDAC6

1

6

High-throughput

0.618

High

272969

ZC11A
Zinc finger CCCH domain-containing protein 11A

2

0

High-throughput

0.602

High

1120716

PDE1C
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

2

0

High-throughput

0.602

High

1198596

NCBP3
Nuclear cap-binding protein subunit 3

2

0

High-throughput

0.602

High

1314845

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

2

0

High-throughput

0.602

High

889606

CLK2
Dual specificity protein kinase CLK2

2

4

High-throughput

0.574

High

506138

PAB4L
Polyadenylate-binding protein 4-like

2

8

High-throughput

0.552

High

175730

SR140
U2 snRNP-associated SURP motif-containing protein

1

10

High-throughput

0.536

High

230547

KIF1C
Kinesin-like protein KIF1C

1

1

High-throughput

0.536

High

284177

SRS10
Serine/arginine-rich splicing factor 10

1

12

High-throughput

0.536

High

346055

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

11

High-throughput

0.536

High

599825

YBOX3
Y-box-binding protein 3

1

2

High-throughput

0.536

High

870965

IREB2
Iron-responsive element-binding protein 2

1

2

High-throughput

0.536

High

961060

MGN
Protein mago nashi homolog

1

2

High-throughput

0.536

High

988152

TRA2B
Transformer-2 protein homolog beta

1

12

High-throughput

0.536

High

994651

YBOX1
Y-box-binding protein 1

1

2

High-throughput

0.536

High

1061052

SRSF1
Serine/arginine-rich splicing factor 1

1

10

High-throughput

0.536

High

1093659

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

2

High-throughput

0.536

High

1111809

TRA2A
Transformer-2 protein homolog alpha

1

10

High-throughput

0.536

High

1129446

PUM1
Pumilio homolog 1

1

6

High-throughput

0.536

High

1145266

RNPS1
RNA-binding protein with serine-rich domain 1

1

12

High-throughput

0.536

High

1148726

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

11

High-throughput

0.536

High

1259116

LARP4
La-related protein 4

1

6

High-throughput

0.536

High

1279862

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

6

High-throughput

0.536

High

1308046

ABC3F
DNA dC->dU-editing enzyme APOBEC-3F

1

2

High-throughput

0.536

High

1314823

PUM2
Pumilio homolog 2

1

6

High-throughput

0.536

High

1314828

ZFR
Zinc finger RNA-binding protein

1

5

High-throughput

0.536

High

1314830

RBM14
RNA-binding protein 14

1

10

High-throughput

0.536

High

1314831

SMG1
Serine/threonine-protein kinase SMG1

1

1

Small-scale

0.536

High

1314836

DHX36
ATP-dependent DNA/RNA helicase DHX36

1

12

High-throughput

0.536

High

1314837

PININ
Pinin

1

1

High-throughput

0.536

High

1314842

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

11

High-throughput

0.536

High

1314844

BCLF1
Bcl-2-associated transcription factor 1

1

4

High-throughput

0.536

High

1314846

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

9

High-throughput

0.536

High

1314849

ABC3B
DNA dC->dU-editing enzyme APOBEC-3B

1

2

High-throughput

0.536

High

1314850

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

4

High-throughput

0.536

High

1314851

RALY
RNA-binding protein Raly

1

1

High-throughput

0.536

High

1314853

SRRM2
Serine/arginine repetitive matrix protein 2

1

8

High-throughput

0.536

High

1314855

TR150
Thyroid hormone receptor-associated protein 3

1

7

High-throughput

0.536

High

1314857

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

11

High-throughput

0.536

High

1203568

ZN326
DBIRD complex subunit ZNF326

1

0

High-throughput

0.513

High

1311578

SUGP2
SURP and G-patch domain-containing protein 2

1

0

High-throughput

0.513

High

422540

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

1314835

NUAK2
NUAK family SNF1-like kinase 2

1

4

High-throughput

0.489

High

242238

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

720122

PURA2
Adenylosuccinate synthetase isozyme 2

1

1

High-throughput

0.479

High

970756

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

979053

RS6
Small ribosomal subunit protein eS6

1

4

High-throughput

0.479

High

980914

H2B1C
Histone H2B type 1-C/E/F/G/I

1

8

High-throughput

0.479

High

992028

RL38
Large ribosomal subunit protein eL38

1

1

High-throughput

0.479

High

1039284

RL6
Large ribosomal subunit protein eL6

1

3

High-throughput

0.479

High

1107909

SQSTM
Sequestosome-1

1

3

High-throughput

0.479

High

1137845

TNIP1
TNFAIP3-interacting protein 1

1

5

High-throughput

0.479

High

1314833

TRI31
E3 ubiquitin-protein ligase TRIM31

1

7

High-throughput

0.479

High

1314841

ZDH18
Palmitoyltransferase ZDHHC18

1

1

Small-scale

0.479

High

1314848

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1314852

RL26L
Ribosomal protein uL24-like

1

4

High-throughput

0.479

High

319896

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

530057

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.445

High

1314822

DND1
Dead end protein homolog 1

1

12

High-throughput

0.445

High

1314854

GAB2
GRB2-associated-binding protein 2

1

5

High-throughput

0.445

High

158846

AP3D1
AP-3 complex subunit delta-1

1

2

High-throughput

0.437

High

372534

MYC
Myc proto-oncogene protein

1

9

High-throughput

0.437

High

406375

MYCN
N-myc proto-oncogene protein

1

9

High-throughput

0.437

High

420610

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.437

High

1254569

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

1258344

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.437

High

1314821

ZDH23
Palmitoyltransferase ZDHHC23

1

2

Small-scale

0.437

High

1314827

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.437

High

1314843

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.437

High

330237

VENTX
Homeobox protein VENTX

1

4

High-throughput

0.407

High

1104014

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.407

High

1314839

ITM2C
Integral membrane protein 2C

1

3

High-throughput

0.407

High

1314856

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

906315

GPC3
Glypican-3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025