HitPredict

Interactor 1: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Interactor 2: CHD1L (Q86WJ1)
Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.-) (Amplified in liver cancer protein 1)
Gene: CHD1L

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	37827155, 19661379
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair GO:0006974 - DNA damage response GO:0035861 - site of double-strand break and 1 others more... GO:0090734 - site of DNA damage
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 616 Hs			1 897
+	Hs
		652312 RFA1_HUMAN (1-616): 0: 781: 100.00		CHD8_HUMAN (1-856): 0: 643: 27.69
+	Hs
		229317 RFA1_HUMAN (1-616): 0: 781: 100.00		SMCA5_HUMAN (9-786): 0: 603: 32.60
+	Hs
		650435 RFA1_HUMAN (1-616): 0: 781: 100.00		SMCA1_HUMAN (35-786): 0: 594: 32.63
+	Hs
		651222 RFA1_HUMAN (1-616): 0: 781: 100.00		CHD4_HUMAN (18-775): 0: 584: 32.19
+	Hs
		650711 RFA1_HUMAN (1-616): 0: 781: 100.00		SMCA4_HUMAN (3-782): 0: 567: 29.03
+	Hs
		650710 RFA1_HUMAN (1-616): 0: 781: 100.00		SMCA2_HUMAN (3-782): 8.8e-177: 555: 28.77
+	Sc
		607354 RFA1_YEAST (4-615): 0: 596: 31.69		ISW2_YEAST (9-808): 0: 576: 31.73
+	Hs
		151381 RFA1_HUMAN (1-616): 0: 781: 100.00		CHD1_HUMAN (40-526): 5.8e-112: 379: 45.51
+	Sc
		607262 RFA1_YEAST (4-615): 0: 596: 31.69		ISW1_YEAST (1-787): 5.28e-178: 546: 31.40