HitPredict - High confidence protein-protein interactions

Interactor 1: PYR1 (P27708)
Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]
Gene: CAD

Interactor 2: PYR1 (P27708)
Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]
Gene: CAD

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.777

Property	Details
Experiments	28552578, 24332717
Identification Methods	biochemical, cosedimentation in solution, x-ray crystallography
Interaction Type	association, direct interaction

Property	Details
Interacting Pfam domains	Amidohydro_1~Amidohydro_1, Amidohydro_1~OTCace, Amidohydro_1~OTCace_N, CPSase_L_D2~CPSase_L_D2, CPSase_L_D2~CPSase_L_D3, CPSase_L_D2~CPSase_sm_chain, CPSase_L_D2~GATase, CPSase_L_D2~MGS, CPSase_L_D3~CPSase_L_D3, CPSase_L_D3~CPSase_sm_chain, CPSase_sm_chain~GATase, GATase~GATase, MGS~MGS, OTCace~OTCace, OTCace~OTCace_N, OTCace_N~OTCace_N
Common GO terms	GO:0001889 - liver development GO:0004070 - aspartate carbamoyltransferase activity GO:0004087 - carbamoyl-phosphate synthase (ammonia) activity GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity GO:0004151 - dihydroorotase activity and 36 others more... GO:0004359 - glutaminase activity GO:0004672 - protein kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process GO:0006225 - UDP biosynthetic process GO:0006228 - UTP biosynthetic process GO:0006541 - glutamine metabolic process GO:0006805 - xenobiotic metabolic process GO:0007507 - heart development GO:0007565 - female pregnancy GO:0007595 - lactation GO:0008270 - zinc ion binding GO:0014075 - response to amine GO:0016020 - membrane GO:0016363 - nuclear matrix GO:0018107 - peptidyl-threonine phosphorylation GO:0019240 - citrulline biosynthetic process GO:0019899 - enzyme binding GO:0031000 - response to caffeine GO:0031100 - animal organ regeneration GO:0032868 - response to insulin GO:0032991 - protein-containing complex GO:0033574 - response to testosterone GO:0042594 - response to starvation GO:0042995 - cell projection GO:0043025 - neuronal cell body GO:0043195 - terminal bouton GO:0044205 - 'de novo' UMP biosynthetic process GO:0046777 - protein autophosphorylation GO:0051414 - response to cortisol GO:0070062 - extracellular exosome GO:0070335 - aspartate binding GO:0071364 - cellular response to epidermal growth factor stimulus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1	2225
Hs

1	2225

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Last updated: 15 Jul 2024