Protein: ODPX
Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)

Gene: ODPX, PDHX
Organism: Homo sapiens
Interactions: 97
UniProt ID: O00330

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005886 - plasma membrane
GO:0006086 - pyruvate decarboxylation to acetyl-CoA

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

132813

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

7

16

Small-scale

0.965

High

132815

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

4

8

Small-scale

0.892

High

132814

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

2

15

Small-scale

0.767

High

132862

HSC20
Iron-sulfur cluster co-chaperone protein HscB

3

2

Small-scale

0.653

High

132857

ATRAP
Type-1 angiotensin II receptor-associated protein

3

0

High-throughput

0.643

High

132848

PDK1
[Pyruvate dehydrogenase

3

9

High-throughput

0.640

High

132831

STA5A
Signal transducer and activator of transcription 5A

2

3

High-throughput

0.628

High

132834

IF2M
Translation initiation factor IF-2, mitochondrial

2

9

High-throughput

0.628

High

132850

PDK3
[Pyruvate dehydrogenase

2

9

High-throughput

0.628

High

132854

PPCEL
Prolyl endopeptidase-like

2

1

High-throughput

0.628

High

132812

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

14

High-throughput

0.618

High

132845

FOXD4
Forkhead box protein D4

2

1

High-throughput

0.574

High

132843

EP300
Histone acetyltransferase p300

1

6

Small-scale

0.561

High

132820

MIF
Macrophage migration inhibitory factor

1

1

High-throughput

0.536

High

132836

STA5B
Signal transducer and activator of transcription 5B

1

3

High-throughput

0.536

High

132853

AAK1
AP2-associated protein kinase 1

1

1

High-throughput

0.536

High

132859

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

3

High-throughput

0.536

High

132878

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

3

High-throughput

0.536

High

132887

HDAC6
Protein deacetylase HDAC6

1

3

High-throughput

0.536

High

132891

HECD1
E3 ubiquitin-protein ligase HECTD1

2

7

High-throughput

0.533

High

132842

EWS
RNA-binding protein EWS

1

0

High-throughput

0.518

High

132895

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

5

High-throughput

0.515

High

132803

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

5

High-throughput

0.501

High

132849

PDK2
[Pyruvate dehydrogenase

1

9

Small-scale

0.501

High

132817

ACTN1
Alpha-actinin-1

1

2

High-throughput

0.481

High

132872

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

2

Small-scale

0.481

High

126352

RHOD
Rho-related GTP-binding protein RhoD

1

8

High-throughput

0.479

High

132804

TMPS2
Transmembrane protease serine 2

1

4

High-throughput

0.479

High

132805

MPPB
Mitochondrial-processing peptidase subunit beta

1

10

High-throughput

0.479

High

132806

RF1M
Peptide chain release factor 1, mitochondrial

1

10

High-throughput

0.479

High

132808

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

5

High-throughput

0.479

High

132809

GCR
Glucocorticoid receptor

1

7

Small-scale

0.479

High

132816

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.479

High

132818

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.479

High

132819

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.479

High

132821

RAC2
Ras-related C3 botulinum toxin substrate 2

1

6

High-throughput

0.479

High

132822

CAN2
Calpain-2 catalytic subunit

1

1

High-throughput

0.479

High

132823

LEG3
Galectin-3

1

3

Small-scale

0.479

High

132825

BRD2
Bromodomain-containing protein 2

1

7

High-throughput

0.479

High

132826

MERL
Merlin

1

3

High-throughput

0.479

High

132829

MDHM
Malate dehydrogenase, mitochondrial

1

4

High-throughput

0.479

High

132830

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

132833

EFTS
Elongation factor Ts, mitochondrial

1

3

High-throughput

0.479

High

132835

EFTU
Elongation factor Tu, mitochondrial

1

6

High-throughput

0.479

High

132837

RHOA
Transforming protein RhoA

1

8

High-throughput

0.479

High

132838

RND3
Rho-related GTP-binding protein RhoE

1

14

High-throughput

0.479

High

132839

RHOB
Rho-related GTP-binding protein RhoB

1

8

High-throughput

0.479

High

132840

RAC1
Ras-related C3 botulinum toxin substrate 1

1

6

High-throughput

0.479

High

132841

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.479

High

132844

MPPA
Mitochondrial-processing peptidase subunit alpha

1

10

High-throughput

0.479

High

132847

NDF1
Neurogenic differentiation factor 1

1

2

Small-scale

0.479

High

132851

RHOH
Rho-related GTP-binding protein RhoH

1

11

High-throughput

0.479

High

132852

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

3

High-throughput

0.479

High

132860

RHOU
Rho-related GTP-binding protein RhoU

1

11

High-throughput

0.479

High

132861

TM11B
Transmembrane protease serine 11B

1

4

High-throughput

0.479

High

132863

MILK2
MICAL-like protein 2

1

4

High-throughput

0.479

High

132867

RND1
Rho-related GTP-binding protein Rho6

1

13

High-throughput

0.479

High

132868

FAKD4
FAST kinase domain-containing protein 4

1

9

High-throughput

0.479

High

132869

RRFM
Ribosome-recycling factor, mitochondrial

1

3

High-throughput

0.479

High

132870

EFGM
Elongation factor G, mitochondrial

1

8

High-throughput

0.479

High

132873

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

132874

TACO1
Translational activator of cytochrome c oxidase 1

1

3

High-throughput

0.479

High

132875

CQ080
Mitochondrial nucleoid-associated protein 1

1

3

High-throughput

0.479

High

132876

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

3

High-throughput

0.479

High

132879

RT26
Small ribosomal subunit protein mS26

1

3

High-throughput

0.479

High

132880

MTG2
Mitochondrial ribosome-associated GTPase 2

1

6

High-throughput

0.479

High

132881

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

132882

MET17
Ribosome assembly protein METTL17, mitochondrial

1

4

High-throughput

0.479

High

132883

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

3

High-throughput

0.479

High

132884

TMPS4
Transmembrane protease serine 4

1

4

High-throughput

0.479

High

132885

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

4

High-throughput

0.479

High

132886

MRES1
Mitochondrial transcription rescue factor 1

1

3

High-throughput

0.479

High

132888

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

10

High-throughput

0.479

High

132889

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

132892

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.479

High

132893

RM11
Large ribosomal subunit protein uL11m

1

3

High-throughput

0.479

High

132894

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

2

Small-scale

0.479

High

48430

ESYT2
Extended synaptotagmin-2

1

0

High-throughput

0.458

High

132828

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.458

High

132877

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.458

High

85087

B7Z207
Protein-serine/threonine kinase

1

9

High-throughput

0.445

High

132810

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

132824

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

132827

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

1

High-throughput

0.445

High

132832

CNDD3
Condensin-2 complex subunit D3

1

3

High-throughput

0.445

High

132811

S10A9
Protein S100-A9

1

0

Small-scale

0.438

High

132802

CHD2
Chromodomain-helicase-DNA-binding protein 2

1

5

High-throughput

0.437

High

132807

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

132846

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

5

High-throughput

0.437

High

132856

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.437

High

132858

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

132866

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.437

High

132864

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.426

High

132855

CP135
Centrosomal protein of 135 kDa

1

9

High-throughput

0.407

High

132865

POC5
Centrosomal protein POC5

1

3

High-throughput

0.407

High

132871

CK5P2
CDK5 regulatory subunit-associated protein 2

1

10

High-throughput

0.407

High

132890

CIDEB
Lipid transferase CIDEB

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025