HitPredict

Interactor 1: PYR1 (P27708)
Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]
Gene: CAD

Interactor 2: RIPK1 (Q13546)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004672 - protein kinase activity GO:0005524 - ATP binding GO:0005829 - cytosol GO:0032991 - protein-containing complex GO:0046777 - protein autophosphorylation
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 2225 Hs			1 671
+	Hs
		201226 PYR1_HUMAN (1-2225): 0: 2858: 100.00		M3K7_HUMAN (4-611): 9.44e-125: 384: 19.18
+	Hs
		653213 PYR1_HUMAN (1-2225): 0: 2858: 100.00		RIPK4_HUMAN (14-280): 7.4e-33: 137: 34.31
+	Hs
		653377 PYR1_HUMAN (1-2225): 0: 2858: 100.00		Q9H4D1_HUMAN (14-281): 1.82e-32: 135: 34.18
+	Hs
		653415 PYR1_HUMAN (1-2225): 0: 2858: 100.00		RIPK3_HUMAN (18-286): 1.57e-32: 134: 33.33
+	Hs
		435544 PYR1_HUMAN (1-2225): 0: 2858: 100.00		IGF1R_HUMAN (20-312): 1.02e-26: 118: 31.21
+	Hs
		653181 PYR1_HUMAN (1-2225): 0: 2858: 100.00		CSK_HUMAN (10-285): 1.03e-27: 118: 30.74