Protein: TDRKH
Tudor and KH domain-containing protein (Tudor domain-containing protein 2)

Gene: TDRKH
Organism: Homo sapiens
Interactions: 84
UniProt ID: Q9Y2W6

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005739 - mitochondrion
GO:0007140 - male meiotic nuclear division
GO:0007283 - spermatogenesis
GO:0009566 - fertilization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1394719

PIWL1
Piwi-like protein 1

4

20

Small-scale

0.694

High

1366635

AKAP1
A-kinase anchor protein 1, mitochondrial

1

12

High-throughput

0.618

High

1278152

MAVS
Mitochondrial antiviral-signaling protein

2

10

High-throughput

0.611

High

1324200

PLD6
Mitochondrial cardiolipin hydrolase

2

3

High-throughput

0.611

High

1335873

ZBT34
Zinc finger and BTB domain-containing protein 34

3

6

High-throughput

0.607

High

1277694

PIWL4
Piwi-like protein 4

2

20

High-throughput

0.601

High

348805

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

6

High-throughput

0.584

High

1451792

MARH5
E3 ubiquitin-protein ligase MARCHF5

2

1

Small-scale

0.584

High

1453326

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

18

Small-scale

0.575

High

1135541

RHG19
Rho GTPase-activating protein 19

2

9

High-throughput

0.574

High

1453395

MTCH1
Mitochondrial carrier homolog 1

2

12

High-throughput

0.571

High

1490975

MTCH2
Mitochondrial carrier homolog 2

2

11

High-throughput

0.571

High

1449209

LANC2
LanC-like protein 2

2

1

High-throughput

0.553

High

352606

TOP3B
DNA topoisomerase 3-beta-1

1

4

High-throughput

0.536

High

1061218

SRSF1
Serine/arginine-rich splicing factor 1

1

20

High-throughput

0.536

High

1143314

PLEC
Plectin

1

4

High-throughput

0.536

High

1144509

NONO
Non-POU domain-containing octamer-binding protein

1

20

High-throughput

0.536

High

1310543

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

1381811

MARC2
Mitochondrial amidoxime reducing component 2

1

2

High-throughput

0.536

High

397275

ESR1
Estrogen receptor

2

20

High-throughput

0.521

High

992668

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.513

High

671877

ZA2G
Zinc-alpha-2-glycoprotein

1

4

High-throughput

0.489

High

1150028

TERF2
Telomeric repeat-binding factor 2

1

3

High-throughput

0.489

High

1386981

GASP2
G-protein coupled receptor-associated sorting protein 2

1

3

High-throughput

0.489

High

1430651

CCDC8
Coiled-coil domain-containing protein 8

1

6

High-throughput

0.489

High

1439512

S10AE
Protein S100-A14

1

2

High-throughput

0.489

High

1459713

SUN2
SUN domain-containing protein 2

1

1

High-throughput

0.489

High

1462773

ZN148
Zinc finger protein 148

1

2

High-throughput

0.489

High

1490972

ZN281
Zinc finger protein 281

1

2

High-throughput

0.489

High

167026

MGST3
Glutathione S-transferase 3, mitochondrial

1

1

High-throughput

0.479

High

245560

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

2

High-throughput

0.479

High

281694

MTX2
Metaxin-2

1

3

High-throughput

0.479

High

326635

MFN2
Mitofusin-2

1

2

High-throughput

0.479

High

611426

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

2

High-throughput

0.479

High

901695

RAB7A
Ras-related protein Rab-7a

1

11

High-throughput

0.479

High

1125744

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

12

High-throughput

0.479

High

1147713

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

3

High-throughput

0.479

High

1312308

MIRO2
Mitochondrial Rho GTPase 2

1

14

High-throughput

0.479

High

1367645

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1382983

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

High-throughput

0.479

High

1394066

COX14
Cytochrome c oxidase assembly protein COX14

1

1

High-throughput

0.479

High

1403830

RMD3
Regulator of microtubule dynamics protein 3

1

2

High-throughput

0.479

High

1406092

PHB2
Prohibitin-2

1

9

High-throughput

0.479

High

1438342

PLRKT
Plasminogen receptor

1

1

High-throughput

0.479

High

1449129

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.479

High

1450472

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

1451761

OCAD1
OCIA domain-containing protein 1

1

2

High-throughput

0.479

High

1490973

FIS1
Mitochondrial fission 1 protein

1

1

High-throughput

0.479

High

1490974

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

1

High-throughput

0.479

High

75163

FM25C
Protein FAM25C

1

1

High-throughput

0.470

High

653672

HEMH
Ferrochelatase, mitochondrial

1

4

High-throughput

0.445

High

75144

FM25A
Protein FAM25A

1

1

High-throughput

0.439

High

278999

PEX14
Peroxisomal membrane protein PEX14

1

1

High-throughput

0.437

High

294560

CD123
Translation initiation factor eIF2 assembly protein

1

6

High-throughput

0.437

High

342379

BRD1
Bromodomain-containing protein 1

1

6

High-throughput

0.437

High

630672

RAB3B
Ras-related protein Rab-3B

1

7

High-throughput

0.437

High

631582

RAB5A
Ras-related protein Rab-5A

1

11

High-throughput

0.437

High

827282

ARL1
ADP-ribosylation factor-like protein 1

1

8

High-throughput

0.437

High

941991

PEX3
Peroxisomal biogenesis factor 3

1

2

High-throughput

0.437

High

1156908

E2F4
Transcription factor E2F4

1

3

High-throughput

0.437

High

1256188

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

1389157

KTI12
Protein KTI12 homolog

1

1

Small-scale

0.437

High

1400286

F193B
Protein FAM193B

1

1

High-throughput

0.437

High

1404855

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.437

High

1431796

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

2

High-throughput

0.437

High

1448048

PXMP2
Peroxisomal membrane protein 2

1

1

High-throughput

0.437

High

1180337

ATG2A
Autophagy-related protein 2 homolog A

1

5

Small-scale

0.407

High

1234750

Q6IPW0
FLJ10404 protein

1

1

High-throughput

0.407

High

1271288

SV2B
Synaptic vesicle glycoprotein 2B

1

1

High-throughput

0.407

High

1363492

S39A7
Zinc transporter SLC39A7

1

2

High-throughput

0.407

High

1398028

MF14A
Hippocampus abundant transcript 1 protein

1

1

High-throughput

0.407

High

1353579

ZFP90
Zinc finger protein 90 homolog

2

0

High-throughput

0.316

High

1415027

SNR25
U11/U12 small nuclear ribonucleoprotein 25 kDa protein

2

0

High-throughput

0.316

High

275203

GGCT
Gamma-glutamylcyclotransferase

1

0

High-throughput

0.279

Low

723973

LCN1
Lipocalin-1

1

0

High-throughput

0.279

Low

1129586

ESPL1
Separin

1

0

High-throughput

0.279

Low

1353804

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.279

Low

1434513

ZN644
Zinc finger protein 644

1

0

High-throughput

0.279

Low

1452488

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.279

Low

1453632

SELN
Selenoprotein N

1

0

High-throughput

0.279

Low

1454046

SENP1
Sentrin-specific protease 1

1

0

High-throughput

0.279

Low

835027

S19A1
Reduced folate transporter

1

0

High-throughput

0.232

Low

844980

EAA2
Excitatory amino acid transporter 2

1

0

High-throughput

0.232

Low

1115509

S12A1
Solute carrier family 12 member 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025