HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: TGFR2 (P37173)
TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
Gene: TGFBR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	26186194, 28514442, 9435577, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0019209 - kinase activator activity
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 567
+	Hs
		655243 P85A_HUMAN (1-724): 0: 596: 100.00		TGFR1_HUMAN (48-548): 3.13e-117: 358: 29.62
+	Hs
		129228 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		TGFR2_HUMAN (1-567): 1.25e-149: 443: 100.00
+	Hs
		129227 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		TGFR1_HUMAN (48-548): 3.13e-117: 358: 29.62
+	Hs
		740024 P55G_HUMAN (271-723): 1.4e-104: 329: 72.31		TGFR2_HUMAN (1-567): 1.25e-149: 443: 100.00
+	Hs
		1044931 P55G_HUMAN (271-723): 1.4e-104: 329: 72.31		AVR2B_HUMAN (69-565): 5.95e-135: 404: 33.79
+	Hs
		433275 YES_HUMAN (568-724): 2.15e-31: 131: 20.61		TGFR2_HUMAN (1-567): 1.25e-149: 443: 100.00
+	Hs
		1086131 P55G_HUMAN (271-723): 1.4e-104: 329: 72.31		AMHR2_HUMAN (240-543): 2.45e-43: 164: 33.33