HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: HD (P42858)
Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]
Gene: HTT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.664

Property	Details
Experiments	23275563, 32814053, 17500595
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid pooling approach, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 3142
+	Hs
		129233 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		HD_HUMAN (1-3142): 0: 5724: 100.00
+	Hs
		791818 P55G_HUMAN (271-723): 1.4e-104: 329: 72.31		HD_HUMAN (1-3142): 0: 5724: 100.00
+	Hs
		787146 RHG25_HUMAN (102-569): 5.14e-63: 224: 15.58		HD_HUMAN (1-3142): 0: 5724: 100.00
+	Hs
		791753 RHG24_HUMAN (94-443): 7.45e-57: 208: 16.76		HD_HUMAN (1-3142): 0: 5724: 100.00
+	Hs
		200207 SRGP3_HUMAN (84-389): 6.03e-55: 206: 15.97		HD_HUMAN (1-3142): 0: 5724: 100.00
+	Hs
		253326 SRGP2_HUMAN (118-668): 3.41e-54: 203: 13.78		HD_HUMAN (1-3142): 0: 5724: 100.00
+	Hs
		791711 SRGP1_HUMAN (86-631): 1.15e-53: 202: 11.88		HD_HUMAN (1-3142): 0: 5724: 100.00
+	Mm
		103089 SRGP3_MOUSE (84-389): 1.06e-53: 202: 15.34		G3X9H5_MOUSE (81-3142): 0: 5479: 91.19
+	Mm
		102849 FYN_MOUSE (573-724): 9.83e-33: 135: 22.50		G3X9H5_MOUSE (81-3142): 0: 5479: 91.19