Protein: TSYL5
Testis-specific Y-encoded-like protein 5 (TSPY-like protein 5)

Gene: TSYL5, TSPYL5
Organism: Homo sapiens
Interactions: 51
UniProt ID: Q86VY4

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0006334 - nucleosome assembly
GO:0008284 - positive regulation of cell population proliferation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

998496

H31
Histone H3.1

1

18

Small-scale

0.724

High

1030938

TSPY1
Testis-specific Y-encoded protein 1

1

14

Small-scale

0.713

High

277732

H2AY
Core histone macro-H2A.1

1

16

High-throughput

0.691

High

1016993

H33
Histone H3.3

1

18

High-throughput

0.691

High

419060

H2A1B
Histone H2A type 1-B/E

1

14

Small-scale

0.647

High

754898

H2B1B
Histone H2B type 1-B

1

19

Small-scale

0.647

High

979920

H4
Histone H4

2

4

Small-scale

0.639

High

1291808

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

10

Small-scale

0.618

High

372464

MYC
Myc proto-oncogene protein

2

5

High-throughput

0.584

High

129759

CBX4
E3 SUMO-protein ligase CBX4

1

4

High-throughput

0.536

High

655257

SFPQ
Splicing factor, proline- and glutamine-rich

1

1

High-throughput

0.536

High

684297

DDX6
Probable ATP-dependent RNA helicase DDX6

1

1

High-throughput

0.536

High

859347

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

960788

RL15
Large ribosomal subunit protein eL15

1

6

High-throughput

0.536

High

978596

RL23A
Large ribosomal subunit protein uL23

1

3

High-throughput

0.536

High

1112306

PWP1
Periodic tryptophan protein 1 homolog

1

4

High-throughput

0.536

High

1144398

NONO
Non-POU domain-containing octamer-binding protein

1

2

High-throughput

0.536

High

1271718

MEPCE
7SK snRNA methylphosphate capping enzyme

1

3

High-throughput

0.536

High

1275544

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

3

High-throughput

0.536

High

1291809

ZFP91
E3 ubiquitin-protein ligase ZFP91

1

8

High-throughput

0.536

High

425559

ISG15
Ubiquitin-like protein ISG15

1

5

High-throughput

0.515

High

542103

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

1210478

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.513

High

1277839

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.513

High

1291811

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.513

High

1291812

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.513

High

1291816

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.513

High

280701

PR40A
Pre-mRNA-processing factor 40 homolog A

1

7

High-throughput

0.489

High

346026

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.489

High

889140

RBM25
RNA-binding protein 25

1

3

High-throughput

0.489

High

984843

RL31
Large ribosomal subunit protein eL31

1

4

High-throughput

0.489

High

986096

RL8
Large ribosomal subunit protein uL2

1

2

High-throughput

0.489

High

996751

TBA1B
Tubulin alpha-1B chain

1

4

High-throughput

0.489

High

1291806

ATX2L
Ataxin-2-like protein

1

1

High-throughput

0.489

High

1291813

DDX24
ATP-dependent RNA helicase DDX24

1

5

High-throughput

0.489

High

1291815

DCA13
DDB1- and CUL4-associated factor 13

1

2

High-throughput

0.489

High

132140

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

5

High-throughput

0.479

High

194254

R113A
E3 ubiquitin-protein ligase RNF113A

1

2

High-throughput

0.479

High

406349

MYCN
N-myc proto-oncogene protein

1

5

High-throughput

0.479

High

537451

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

904893

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

937808

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.479

High

1113584

CUL3
Cullin-3

1

11

High-throughput

0.479

High

1291807

ESR2
Estrogen receptor beta

1

9

High-throughput

0.479

High

1291817

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1045467

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1291810

CI072
Guanine nucleotide exchange factor C9orf72

1

3

Small-scale

0.445

High

809708

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.279

Low

1205067

FA76B
Protein FAM76B

1

0

High-throughput

0.279

Low

1248034

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

0

High-throughput

0.279

Low

1291814

DDX21
Nucleolar RNA helicase 2

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025