HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: DDR1 (Q08345)
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
Gene: DDR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	35384245, 22057045
Identification Methods	proximity labelling technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 913
+	Hs
		522796 P85A_HUMAN (1-724): 0: 596: 100.00		SRC_HUMAN (361-912): 1.28e-125: 391: 23.60
+	Hs
		609182 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR3_HUMAN (551-905): 1.32e-110: 360: 32.16
+	Hs
		601463 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR2_HUMAN (583-905): 4.2e-109: 357: 34.05
+	Hs
		507870 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52
+	Hs
		607886 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR4_HUMAN (554-910): 8.48e-107: 350: 33.87
+	Hs
		655389 P85A_HUMAN (1-724): 0: 596: 100.00		NTRK2_HUMAN (604-906): 1.75e-104: 345: 43.89
+	Hs
		433263 P85A_HUMAN (1-724): 0: 596: 100.00		YES_HUMAN (563-907): 1.25e-105: 339: 31.59
+	Hs
		129185 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		SRC_HUMAN (361-912): 1.28e-125: 391: 23.60
+	Hs
		129184 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52
+	Hs
		655387 P85A_HUMAN (1-724): 0: 596: 100.00		NTRK3_HUMAN (607-905): 4.06e-67: 242: 43.63
+	Hs
		384316 P85A_HUMAN (1-724): 0: 596: 100.00		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Hs
		655320 P85A_HUMAN (1-724): 0: 596: 100.00		ROR1_HUMAN (604-902): 1.59e-55: 209: 37.79
+	Hs
		411306 P85A_HUMAN (1-724): 0: 596: 100.00		INSR_HUMAN (600-908): 7.71e-53: 202: 37.42
+	Hs
		435546 P85A_HUMAN (1-724): 0: 596: 100.00		IGF1R_HUMAN (600-908): 4.51e-51: 197: 37.22
+	Mm
		546262 P85A_MOUSE (1-724): 0: 592: 95.99		INSR_MOUSE (600-908): 1.88e-51: 198: 36.77
+	Hs
		655321 P85A_HUMAN (1-724): 0: 596: 100.00		ROR2_HUMAN (608-905): 1.57e-50: 194: 38.26
+	Rn
		544879 P85A_RAT (1-724): 0: 580: 94.20		INSR_RAT (600-908): 1.98e-51: 198: 36.25
+	Hs
		129160 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Hs
		129162 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		INSR_HUMAN (600-908): 7.71e-53: 202: 37.42
+	Hs
		129171 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		IGF1R_HUMAN (600-908): 4.51e-51: 197: 37.22