HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: TENS4 (Q8IZW8)
Tensin-4 (C-terminal tensin-like protein)
Gene: TNS4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PI3K_P85_iSH2~SH2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 715
+	Hs
		655332 P85A_HUMAN (1-724): 0: 596: 100.00		SOS1_HUMAN (26-311): 8.31e-22: 103: 14.15
+	Hs
		522796 P85A_HUMAN (1-724): 0: 596: 100.00		SRC_HUMAN (287-582): 1.42e-21: 100: 14.56
+	Hs
		129185 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		SRC_HUMAN (287-582): 1.42e-21: 100: 14.56
+	Hs
		523089 P55G_HUMAN (271-723): 1.4e-104: 329: 72.31		SRC_HUMAN (287-582): 1.42e-21: 100: 14.56
+	Hs
		64648 RHG32_HUMAN (14-613): 1.13e-61: 227: 13.99		SRC_HUMAN (287-582): 1.42e-21: 100: 14.56
+	Hs
		523026 RHG17_HUMAN (41-350): 6.97e-54: 201: 18.50		SRC_HUMAN (287-582): 1.42e-21: 100: 14.56
+	Hs
		1133704 RHG21_HUMAN (78-531): 1.19e-59: 221: 13.46		PRR36_HUMAN (13-553): 1.43e-10: 67.1: 11.03
+	Hs
		433231 YES_HUMAN (568-724): 2.15e-31: 131: 20.61		SRC_HUMAN (287-582): 1.42e-21: 100: 14.56