Protein: RPD3
Histone deacetylase RPD3 (EC 3.5.1.98) (Transcriptional regulatory protein RPD3)

Gene: RPD3
Organism: Saccharomyces cerevisiae S288C
Interactions: 135
UniProt ID: P32561

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003713 - transcription coactivator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

649933

SIN3
Transcriptional regulatory protein SIN3

23

19

Small-scale

0.989

High

739894

PHO23
Transcriptional regulatory protein PHO23

14

5

Small-scale

0.982

High

739914

RCO1
Transcriptional regulatory protein RCO1

12

20

Small-scale

0.980

High

739859

RXT2
Transcriptional regulatory protein RXT2

14

0

Small-scale

0.932

High

739882

SDS3
Transcriptional regulatory protein SDS3

13

0

Small-scale

0.929

High

726258

DEP1
Transcriptional regulatory protein DEP1

10

0

Small-scale

0.923

High

739901

H3
Histone H3

4

18

Small-scale

0.878

High

739845

RPD3
Histone deacetylase RPD3

3

15

Small-scale

0.827

High

739922

CTI6
Histone deacetylase complex subunit CTI6

13

6

Small-scale

0.758

High

739928

EAF3
Chromatin modification-related protein EAF3

9

6

Small-scale

0.752

High

739908

UME1
Transcriptional regulatory protein UME1

14

0

Small-scale

0.728

High

739861

SAP30
Transcriptional regulatory protein SAP30

12

0

Small-scale

0.726

High

739917

RXT3
Transcriptional regulatory protein RXT3

8

0

Small-scale

0.717

High

739910

ECM5
Protein ECM5

1

15

Small-scale

0.715

High

739853

ASH1
Transcriptional regulatory protein ASH1

7

0

Small-scale

0.709

High

739866

UME6
Transcriptional regulatory protein UME6

6

0

Small-scale

0.697

High

739896

SNT2
E3 ubiquitin-protein ligase SNT2

1

8

Small-scale

0.691

High

739930

H2AZ
Histone H2A.Z

1

15

Small-scale

0.647

High

415213

TOP1
DNA topoisomerase 1

2

2

High-throughput

0.621

High

585886

CSK21
Casein kinase II subunit alpha

2

16

High-throughput

0.621

High

739890

CYP7
Peptidyl-prolyl cis-trans isomerase CYP7

2

7

Small-scale

0.620

High

739899

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

2

7

Small-scale

0.620

High

577539

CYC8
General transcriptional corepressor CYC8

2

11

Small-scale

0.618

High

598383

TUP1
General transcriptional corepressor TUP1

2

20

Small-scale

0.612

High

709636

BMH1
Protein BMH1

2

8

Small-scale

0.594

High

739864

CSK2C
Casein kinase II subunit beta'

2

1

High-throughput

0.588

High

739858

NU170
Nucleoporin NUP170

2

1

Small-scale

0.584

High

739883

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.584

High

739919

CDC45
Cell division control protein 45

2

0

High-throughput

0.576

High

381020

H2B1
Histone H2B.1

1

20

High-throughput

0.575

High

739906

ADA2
SAGA complex subunit ADA2

1

4

High-throughput

0.575

High

638985

VPS1
Vacuolar protein sorting-associated protein 1

2

0

High-throughput

0.563

High

739851

NCBP1
Nuclear cap-binding protein complex subunit 1

2

0

High-throughput

0.563

High

739898

NRD1
Protein NRD1

2

0

High-throughput

0.563

High

646347

RAD53
Serine/threonine-protein kinase RAD53

1

6

Small-scale

0.561

High

739895

INO80
Chromatin-remodeling ATPase INO80

1

20

Small-scale

0.561

High

739877

SSB2
Ribosome-associated molecular chaperone SSB2

2

19

High-throughput

0.552

High

433168

RL17A
Large ribosomal subunit protein uL22A

1

5

High-throughput

0.536

High

739892

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

10

High-throughput

0.536

High

739911

GCN5
Histone acetyltransferase GCN5

1

20

High-throughput

0.536

High

739852

SIP2
SNF1 protein kinase subunit beta-2

1

0

Small-scale

0.527

High

575911

CYPH
Peptidyl-prolyl cis-trans isomerase

1

6

Small-scale

0.515

High

651912

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

1

Small-scale

0.515

High

739927

WHI5
G1-specific transcriptional repressor WHI5

1

1

Small-scale

0.515

High

598831

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

6

Small-scale

0.500

High

739867

TCPB
T-complex protein 1 subunit beta

1

20

Small-scale

0.500

High

739886

TCPH
T-complex protein 1 subunit eta

1

20

Small-scale

0.500

High

739891

RS12
Small ribosomal subunit protein eS12

1

2

Small-scale

0.500

High

739889

MTC1
Maintenance of telomere capping protein 1

1

0

High-throughput

0.493

High

739909

HOT1
High-osmolarity-induced transcription protein 1

1

0

Small-scale

0.493

High

433990

RL33A
Large ribosomal subunit protein eL33A

1

2

High-throughput

0.489

High

738137

NGG1
SAGA complex subunit NGG1

1

0

Small-scale

0.480

High

381960

H4
Histone H4

1

13

High-throughput

0.479

High

594261

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

Small-scale

0.479

High

647055

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.479

High

706532

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

726853

HS104
Heat shock protein 104

1

2

High-throughput

0.479

High

734396

BTAF1
TATA-binding protein-associated factor MOT1

1

20

Small-scale

0.479

High

734890

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

737803

HOG1
Mitogen-activated protein kinase HOG1

1

7

Small-scale

0.479

High

739854

BMH2
Protein BMH2

1

8

Small-scale

0.479

High

739857

GBLP
Small ribosomal subunit protein RACK1

1

14

Small-scale

0.479

High

739860

HSL7
Protein arginine N-methyltransferase HSL7

1

1

Small-scale

0.479

High

739862

MIP6
RNA-binding protein MIP6

1

8

Small-scale

0.479

High

739900

ARP5
Actin-related protein 5

1

9

Small-scale

0.479

High

739912

NHP10
Non-histone protein 10

1

20

Small-scale

0.479

High

739916

TOS4
Protein TOS4

1

2

Small-scale

0.479

High

739923

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

739926

ARP8
Actin-like protein ARP8

1

13

Small-scale

0.479

High

739929

CMR1
DNA damage-binding protein CMR1

1

20

High-throughput

0.479

High

739931

SMC6
Structural maintenance of chromosomes protein 6

1

17

High-throughput

0.479

High

739847

IES6
Chromatin-remodeling complex subunit IES6

1

0

Small-scale

0.458

High

739849

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

739856

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

739865

ASPG1
L-asparaginase 1

1

0

High-throughput

0.458

High

739876

IES5
Ino eighty subunit 5

1

0

Small-scale

0.458

High

739878

IES2
Ino eighty subunit 2

1

0

Small-scale

0.458

High

739879

ATG3
Autophagy-related protein 3

1

0

Small-scale

0.458

High

739881

XBP1
Transcriptional repressor XBP1

1

0

Small-scale

0.458

High

739884

HAC1
Transcriptional activator HAC1

1

0

Small-scale

0.458

High

739887

IES1
Ino eighty subunit 1

1

0

Small-scale

0.458

High

739893

TAF4
Transcription initiation factor TFIID subunit 4

1

0

High-throughput

0.458

High

739913

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.458

High

739915

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

739918

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

739920

SGO1
Shugoshin

1

0

High-throughput

0.458

High

739921

IES4
Ino eighty subunit 4

1

0

Small-scale

0.458

High

739925

IES3
Ino eighty subunit 3

1

0

Small-scale

0.458

High

383104

RLA4
Large ribosomal subunit protein P2B

1

3

Small-scale

0.457

High

427680

RLA2
Large ribosomal subunit protein P2A

1

3

Small-scale

0.457

High

456365

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

1

Small-scale

0.457

High

514117

RS16B
Small ribosomal subunit protein uS9B

1

3

Small-scale

0.457

High

553963

TCPA
T-complex protein 1 subunit alpha

1

20

Small-scale

0.457

High

739868

TCPG
T-complex protein 1 subunit gamma

1

20

Small-scale

0.457

High

739869

TCPD
T-complex protein 1 subunit delta

1

20

Small-scale

0.457

High

739870

TCPZ
T-complex protein 1 subunit zeta

1

20

Small-scale

0.457

High

739880

TCPE
T-complex protein 1 subunit epsilon

1

20

Small-scale

0.457

High

739902

ACAC
Acetyl-CoA carboxylase

1

15

Small-scale

0.457

High

376216

RAS2
Ras-like protein 2

1

7

Small-scale

0.445

High

403415

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

6

High-throughput

0.445

High

427186

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.445

High

432523

RL7A
Large ribosomal subunit protein uL30A

1

4

High-throughput

0.445

High

434936

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.445

High

512744

RS6B
Small ribosomal subunit protein eS6B

1

3

Small-scale

0.445

High

523384

HSP71
Heat shock protein SSA1

1

18

High-throughput

0.445

High

526200

HSP72
Heat shock protein SSA2

1

18

High-throughput

0.445

High

544199

SSB1
Ribosome-associated molecular chaperone SSB1

1

19

High-throughput

0.445

High

670482

SIS1
Protein SIS1

1

8

High-throughput

0.445

High

671601

SCJ1
DnaJ-related protein SCJ1

1

7

High-throughput

0.445

High

675824

MAS5
Mitochondrial protein import protein MAS5

1

8

High-throughput

0.445

High

739846

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

739855

SPT7
SAGA complex subunit SPT7

1

20

High-throughput

0.445

High

739871

CAJ1
Protein CAJ1

1

9

High-throughput

0.445

High

739875

PFD2
Prefoldin subunit 2

1

2

High-throughput

0.445

High

739885

RL10
Large ribosomal subunit protein uL16

1

5

High-throughput

0.445

High

739904

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

20

High-throughput

0.445

High

739924

RL7B
Large ribosomal subunit protein uL30B

1

4

High-throughput

0.445

High

432995

RL6B
Large ribosomal subunit protein eL6B

1

4

Small-scale

0.437

High

512330

RS6A
Small ribosomal subunit protein eS6A

1

3

Small-scale

0.437

High

515232

RL35A
Large ribosomal subunit protein uL29A

1

2

High-throughput

0.437

High

739848

CACP
Carnitine O-acetyltransferase, mitochondrial

1

1

High-throughput

0.437

High

739874

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

739863

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.426

High

739873

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

739903

UBC7
Ubiquitin-conjugating enzyme E2 7

1

6

High-throughput

0.417

High

570226

RS17B
Small ribosomal subunit protein eS17B

1

4

High-throughput

0.407

High

655419

RS3A2
Small ribosomal subunit protein eS1B

1

6

High-throughput

0.407

High

712526

RL8B
Large ribosomal subunit protein eL8B

1

3

High-throughput

0.407

High

739850

RS3A1
Small ribosomal subunit protein eS1A

1

6

High-throughput

0.407

High

739872

RS14B
Small ribosomal subunit protein uS11B

1

2

High-throughput

0.407

High

739888

RL17B
Large ribosomal subunit protein uL22B

1

5

High-throughput

0.407

High

739905

RL6A
Large ribosomal subunit protein eL6A

1

4

High-throughput

0.407

High

739897

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

1

0

High-throughput

0.269

Low

739907

GLRX5
Monothiol glutaredoxin-5, mitochondrial

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025