HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: DOK1 (Q99704)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
Gene: DOK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	11071635, 22974441
Identification Methods	pull down, unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 481
+	Mm
		643076 P85A_MOUSE (1-724): 0: 592: 95.99		DOK1_MOUSE (1-481): 0: 549: 83.23
+	Hs
		151716 P85A_HUMAN (1-724): 0: 596: 100.00		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Hs
		655240 P85A_HUMAN (1-724): 0: 596: 100.00		IRS1_HUMAN (6-373): 1.95e-76: 262: 16.33
+	Mm
		643063 P85A_MOUSE (1-724): 0: 592: 95.99		IRS1_MOUSE (6-373): 1.1e-77: 265: 17.27
+	Rn
		724634 P85A_RAT (1-724): 0: 580: 94.20		IRS1_RAT (6-373): 3.69e-78: 267: 17.27
+	Mm
		643075 P85A_MOUSE (1-724): 0: 592: 95.99		IRS2_MOUSE (6-371): 1.55e-70: 245: 15.10
+	Hs
		655516 P85A_HUMAN (1-724): 0: 596: 100.00		IRS2_HUMAN (6-384): 1.12e-67: 237: 14.05
+	Rn
		94391 P85A_RAT (1-724): 0: 580: 94.20		F1MAL5_RAT (6-371): 8.44e-69: 240: 15.10
+	Hs
		129141 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Rn
		139726 P85A_RAT (1-724): 0: 580: 94.20		O08724_RAT (7-315): 2.1e-60: 207: 19.09
+	Hs
		129219 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		IRS1_HUMAN (6-373): 1.95e-76: 262: 16.33
+	Hs
		433460 YES_HUMAN (568-724): 2.15e-31: 131: 20.61		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		151857 P55G_HUMAN (271-723): 1.4e-104: 329: 72.31		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Hs
		724554 P55G_HUMAN (271-723): 1.4e-104: 329: 72.31		IRS1_HUMAN (6-373): 1.95e-76: 262: 16.33
+	Hs
		1267462 P55G_HUMAN (271-723): 1.4e-104: 329: 72.31		IRS2_HUMAN (6-384): 1.12e-67: 237: 14.05
+	Hs
		151840 RHG24_HUMAN (94-443): 7.45e-57: 208: 16.76		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Hs
		207359 P55G_HUMAN (271-723): 1.4e-104: 329: 72.31		FRS3_HUMAN (153-432): 4e-52: 185: 20.42
+	Hs
		235037 YES_HUMAN (568-724): 2.15e-31: 131: 20.61		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Dm
		113958 M9PAY7_DROME (322-428): 1.98e-13: 71.4: 27.78		IRS1_DROME (26-343): 3.54e-69: 239: 15.03
+	Dm
		186292 O18683_DROME (319-465): 9.73e-10: 63.5: 20.95		IRS1_DROME (26-343): 3.54e-69: 239: 15.03