Protein: MED18
Mediator of RNA polymerase II transcription subunit 18 (Mediator complex subunit 18) (Suppressor of RNA polymerase B 5)

Gene: MED18, SRB5
Organism: Saccharomyces cerevisiae S288C
Interactions: 87
UniProt ID: P32585

Gene Ontology (top 5):
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding
GO:0001113 - transcription open complex formation at RNA polymerase II promoter
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

693917

MED8
Mediator of RNA polymerase II transcription subunit 8

20

1

Small-scale

0.987

High

693518

MED17
Mediator of RNA polymerase II transcription subunit 17

23

0

Small-scale

0.939

High

693913

MED20
Mediator of RNA polymerase II transcription subunit 20

14

0

Small-scale

0.933

High

693579

MED22
Mediator of RNA polymerase II transcription subunit 22

9

0

Small-scale

0.919

High

693950

MED11
Mediator of RNA polymerase II transcription subunit 11

8

0

Small-scale

0.915

High

375323

RPB1
DNA-directed RNA polymerase II subunit RPB1

8

0

Small-scale

0.907

High

693943

MED7
Mediator of RNA polymerase II transcription subunit 7

16

1

Small-scale

0.761

High

586275

MED15
Mediator of RNA polymerase II transcription subunit 15

15

0

Small-scale

0.727

High

581343

MED14
Mediator of RNA polymerase II transcription subunit 14

14

0

Small-scale

0.727

High

693945

MED2
Mediator of RNA polymerase II transcription subunit 2

13

0

Small-scale

0.724

High

693946

MED1
Mediator of RNA polymerase II transcription subunit 1

12

0

Small-scale

0.724

High

693935

MED5
Mediator of RNA polymerase II transcription subunit 5

10

0

Small-scale

0.722

High

686832

MED16
Mediator of RNA polymerase II transcription subunit 16

9

0

Small-scale

0.720

High

693927

MED3
Mediator of RNA polymerase II transcription subunit 3

10

0

Small-scale

0.720

High

693920

MED6
Mediator of RNA polymerase II transcription subunit 6

10

0

Small-scale

0.720

High

693947

MED4
Mediator of RNA polymerase II transcription subunit 4

9

0

Small-scale

0.717

High

626017

MED19
Mediator of RNA polymerase II transcription subunit 19

8

0

Small-scale

0.714

High

693910

MED9
Mediator of RNA polymerase II transcription subunit 9

8

0

Small-scale

0.714

High

693941

MED10
Mediator of RNA polymerase II transcription subunit 10

6

0

Small-scale

0.697

High

693919

MED31
Mediator of RNA polymerase II transcription subunit 31

6

0

Small-scale

0.696

High

693923

SSN3
Meiotic mRNA stability protein kinase SSN3

5

0

Small-scale

0.690

High

693922

SSN2
Mediator of RNA polymerase II transcription subunit 13

5

0

Small-scale

0.678

High

693934

MED21
Mediator of RNA polymerase II transcription subunit 21

5

0

Small-scale

0.678

High

693930

T2FB
Transcription initiation factor IIF subunit beta

4

0

Small-scale

0.651

High

693907

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

High-throughput

0.631

High

557952

RPB3
DNA-directed RNA polymerase II subunit RPB3

3

0

Small-scale

0.628

High

635984

SRB8
Mediator of RNA polymerase II transcription subunit 12

3

0

Small-scale

0.613

High

693933

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

2

0

Small-scale

0.595

High

680545

HS104
Heat shock protein 104

2

1

High-throughput

0.588

High

693926

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

High-throughput

0.588

High

526972

TBP
TATA-box-binding protein

2

0

Small-scale

0.585

High

661676

TF2B
Transcription initiation factor IIB

2

0

Small-scale

0.585

High

356341

H4
Histone H4

2

0

Small-scale

0.577

High

693918

PAF1
RNA polymerase II-associated protein 1

2

0

Small-scale

0.559

High

693942

CDC73
Cell division control protein 73

2

0

Small-scale

0.559

High

490677

HSP71
Heat shock protein SSA1

2

2

High-throughput

0.552

High

440000

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

0

Small-scale

0.547

High

543411

HSC82
ATP-dependent molecular chaperone HSC82

2

1

High-throughput

0.521

High

636564

CDC48
Cell division control protein 48

1

0

High-throughput

0.493

High

693924

HAT2
Histone acetyltransferase type B subunit 2

1

0

High-throughput

0.493

High

693932

MTR4
ATP-dependent RNA helicase DOB1

1

0

High-throughput

0.493

High

693948

ARP8
Actin-like protein ARP8

1

0

High-throughput

0.493

High

514159

NHP6A
Non-histone chromosomal protein 6A

1

1

Small-scale

0.481

High

514241

NHP6B
Non-histone chromosomal protein 6B

1

1

Small-scale

0.481

High

355403

H2B1
Histone H2B.1

1

0

Small-scale

0.480

High

693936

H3
Histone H3

1

0

Small-scale

0.480

High

449967

HSP73
Heat shock protein SSA3

1

2

Small-scale

0.479

High

693938

STE20
Serine/threonine-protein kinase STE20

1

0

Small-scale

0.460

High

381534

GAL4
Regulatory protein GAL4

1

0

Small-scale

0.458

High

561856

TUP1
General transcriptional corepressor TUP1

1

0

Small-scale

0.458

High

593048

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

Small-scale

0.458

High

593123

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

Small-scale

0.458

High

593218

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

Small-scale

0.458

High

593298

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

Small-scale

0.458

High

628747

RNA14
mRNA 3'-end-processing protein RNA14

1

0

Small-scale

0.458

High

655549

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

Small-scale

0.458

High

687671

BTAF1
TATA-binding protein-associated factor MOT1

1

0

Small-scale

0.458

High

693914

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

693915

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

693921

RPB11
DNA-directed RNA polymerase II subunit RPB11

1

0

Small-scale

0.458

High

693929

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

Small-scale

0.458

High

693937

IMA1
Importin subunit alpha

1

0

High-throughput

0.458

High

693940

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

365998

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.445

High

493489

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

510657

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.445

High

693908

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

693909

HSP79
Heat shock protein homolog SSE2

1

4

High-throughput

0.445

High

560605

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

627836

SIS1
Protein SIS1

1

0

High-throughput

0.426

High

478024

HSP77
Import motor subunit, mitochondrial

1

2

High-throughput

0.407

High

693912

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.407

High

693925

HSP7E
Heat shock protein SSC3, mitochondrial

1

2

High-throughput

0.407

High

693939

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

5

High-throughput

0.407

High

367873

EF1A
Elongation factor 1-alpha

2

0

Small-scale

0.313

High

399379

RLA0
Large ribosomal subunit protein uL10

1

0

Small-scale

0.279

Low

693916

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

Small-scale

0.279

Low

693911

DHE2
NAD-specific glutamate dehydrogenase

1

0

High-throughput

0.269

Low

693931

RS10B
Small ribosomal subunit protein eS10B

1

0

High-throughput

0.269

Low

500624

TIR1
Cold shock-induced protein TIR1

1

0

High-throughput

0.249

Low

599964

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

0

High-throughput

0.249

Low

628786

RNA15
mRNA 3'-end-processing protein RNA15

1

0

Small-scale

0.249

Low

693949

IRC11
Putative increased recombination centers protein 11

1

0

High-throughput

0.249

Low

443926

CYAA
Adenylate cyclase

1

0

Small-scale

0.232

Low

693928

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.232

Low

693944

TFB4
General transcription and DNA repair factor IIH subunit TFB4

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024