HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	35384245, 16135792
Identification Methods	proximity labelling technology, affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 1620
+	Hs
		655225 P85A_HUMAN (1-724): 0: 596: 100.00		LTK_HUMAN (606-1458): 6.35e-175: 550: 53.24
+	Hs
		434140 P85A_HUMAN (1-724): 0: 596: 100.00		RET_HUMAN (842-1477): 4.8e-137: 455: 23.56
+	Mm
		643062 P85A_MOUSE (1-724): 0: 592: 95.99		RET_MOUSE (843-1477): 2.28e-128: 431: 23.21
+	Hs
		655377 P85A_HUMAN (1-724): 0: 596: 100.00		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Hs
		655222 P85A_HUMAN (1-724): 0: 596: 100.00		EPHB2_HUMAN (938-1436): 2.19e-123: 416: 23.26
+	Hs
		601463 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR2_HUMAN (952-1433): 9.52e-123: 407: 25.24
+	Hs
		655254 P85A_HUMAN (1-724): 0: 596: 100.00		ABL2_HUMAN (1103-1526): 1.55e-118: 405: 32.47
+	Hs
		655220 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA3_HUMAN (943-1427): 7.27e-120: 404: 25.87
+	Hs
		609182 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR3_HUMAN (952-1449): 6.42e-121: 401: 26.31
+	Hs
		507870 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Hs
		411306 P85A_HUMAN (1-724): 0: 596: 100.00		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Mm
		546262 P85A_MOUSE (1-724): 0: 592: 95.99		INSR_MOUSE (973-1484): 6.89e-113: 392: 32.38
+	Hs
		435546 P85A_HUMAN (1-724): 0: 596: 100.00		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		655366 P85A_HUMAN (1-724): 0: 596: 100.00		FAK2_HUMAN (1054-1518): 4.66e-109: 374: 27.45
+	Hs
		655389 P85A_HUMAN (1-724): 0: 596: 100.00		NTRK2_HUMAN (1093-1375): 7.35e-64: 236: 41.44
+	Hs
		384316 P85A_HUMAN (1-724): 0: 596: 100.00		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		561382 P85A_HUMAN (1-724): 0: 596: 100.00		FER_HUMAN (1101-1377): 1.53e-59: 223: 40.35
+	Hs
		655387 P85A_HUMAN (1-724): 0: 596: 100.00		NTRK3_HUMAN (1093-1375): 2.69e-59: 223: 39.03
+	Hs
		426946 P85A_HUMAN (1-724): 0: 596: 100.00		FES_HUMAN (1114-1384): 4.5e-59: 222: 42.80
+	Mm
		643079 P85A_MOUSE (1-724): 0: 592: 95.99		UFO_MOUSE (1039-1393): 3.29e-55: 211: 35.60