HitPredict

Interactor 1: DMA (P28067)
HLA class II histocompatibility antigen, DM alpha chain (MHC class II antigen DMA) (Really interesting new gene 6 protein)
Gene: HLA-DMA

Interactor 2: DMB (P28068)
HLA class II histocompatibility antigen, DM beta chain (MHC class II antigen DMB) (Really interesting new gene 7 protein)
Gene: HLA-DMB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 9768757, 23222639, 21131964
Identification Methods x-ray crystallography, molecular sieving, anti tag coimmunoprecipitation, surface plasmon resonance
Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains C1-set~C1-set, C1-set~MHC_II_beta, C1-set~MHC_II_alpha, MHC_II_alpha~MHC_II_beta
Common GO terms GO:0002250 - adaptive immune response
GO:0002503 - peptide antigen assembly with MHC class II protein complex
GO:0005765 - lysosomal membrane
GO:0019886 - antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0023026 - MHC class II protein complex binding
and 6 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024