HitPredict

Interactor 1: PSB4 (P28070)
Proteasome subunit beta type-4 (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3)
Gene: PSMB4

Interactor 2: SYVN1 (Q86TM6)
E3 ubiquitin-protein ligase synoviolin (EC 2.3.2.27) (RING-type E3 ubiquitin transferase synoviolin) (Synovial apoptosis inhibitor 1)
Gene: SYVN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	22119785
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 264 Hs			1 617
+	Hs
		656265 PSA5_HUMAN (26-252): 6.98e-77: 234: 13.69		SYVN1_HUMAN (1-617): 3.41e-151: 451: 100.00
+	Hs
		156321 PSA7_HUMAN (33-255): 6.14e-76: 232: 14.16		SYVN1_HUMAN (1-617): 3.41e-151: 451: 100.00
+	Hs
		637713 PSA2_HUMAN (28-258): 1.95e-74: 228: 14.23		SYVN1_HUMAN (1-617): 3.41e-151: 451: 100.00
+	Hs
		893702 PSA6_HUMAN (26-261): 3.03e-74: 228: 11.69		SYVN1_HUMAN (1-617): 3.41e-151: 451: 100.00
+	Hs
		1198660 PSB7_HUMAN (51-253): 3.22e-70: 219: 18.23		SYVN1_HUMAN (1-617): 3.41e-151: 451: 100.00
+	Hs
		656739 PSB5_HUMAN (11-252): 1.96e-70: 218: 21.07		SYVN1_HUMAN (1-617): 3.41e-151: 451: 100.00
+	Hs
		656541 PSB4_HUMAN (1-264): 6.75e-82: 248: 100.00		AMFR_HUMAN (35-572): 1.29e-85: 281: 19.33
+	Hs
		656334 PSA5_HUMAN (26-252): 6.98e-77: 234: 13.69		AMFR_HUMAN (35-572): 1.29e-85: 281: 19.33
+	Hs
		156372 PSA7_HUMAN (33-255): 6.14e-76: 232: 14.16		AMFR_HUMAN (35-572): 1.29e-85: 281: 19.33
+	Hs
		637752 PSA2_HUMAN (28-258): 1.95e-74: 228: 14.23		AMFR_HUMAN (35-572): 1.29e-85: 281: 19.33
+	Hs
		893769 PSA6_HUMAN (26-261): 3.03e-74: 228: 11.69		AMFR_HUMAN (35-572): 1.29e-85: 281: 19.33
+	Hs
		1303493 PSB7_HUMAN (51-253): 3.22e-70: 219: 18.23		AMFR_HUMAN (35-572): 1.29e-85: 281: 19.33
+	Mm
		610550 PSB8_MOUSE (3-252): 2.34e-72: 224: 23.64		CBL_MOUSE (160-612): 2.32e-49: 186: 13.97
+	Hs
		156325 PSA7_HUMAN (33-255): 6.14e-76: 232: 14.16		RN149_HUMAN (159-423): 6.7e-35: 138: 17.98
+	Hs
		656500 PSB4_HUMAN (1-264): 6.75e-82: 248: 100.00		GOLI_HUMAN (218-396): 3.58e-27: 116: 19.36
+	Hs
		656744 PSB5_HUMAN (11-252): 1.96e-70: 218: 21.07		RN149_HUMAN (159-423): 6.7e-35: 138: 17.98
+	Hs
		156322 PSA7_HUMAN (33-255): 6.14e-76: 232: 14.16		GOLI_HUMAN (218-396): 3.58e-27: 116: 19.36
+	Hs
		637715 PSA2_HUMAN (28-258): 1.95e-74: 228: 14.23		GOLI_HUMAN (218-396): 3.58e-27: 116: 19.36
+	Hs
		893707 PSA6_HUMAN (26-261): 3.03e-74: 228: 11.69		GOLI_HUMAN (218-396): 3.58e-27: 116: 19.36
+	Hs
		656740 PSB5_HUMAN (11-252): 1.96e-70: 218: 21.07		GOLI_HUMAN (218-396): 3.58e-27: 116: 19.36