HitPredict

Interactor 1: PSB4 (P28070)
Proteasome subunit beta type-4 (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3)
Gene: PSMB4

Interactor 2: UCHL5 (Q9Y5K5)
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5)
Gene: UCHL5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	35271311, 34761751, 18922472, 19490896
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 264 Hs			1 329
+	Hs
		656348 PSA5_HUMAN (26-252): 6.98e-77: 234: 13.69		UCHL5_HUMAN (1-329): 1.1e-175: 491: 100.00
+	Hs
		156384 PSA7_HUMAN (33-255): 6.14e-76: 232: 14.16		UCHL5_HUMAN (1-329): 1.1e-175: 491: 100.00
+	Hs
		637763 PSA2_HUMAN (28-258): 1.95e-74: 228: 14.23		UCHL5_HUMAN (1-329): 1.1e-175: 491: 100.00
+	Hs
		893779 PSA6_HUMAN (26-261): 3.03e-74: 228: 11.69		UCHL5_HUMAN (1-329): 1.1e-175: 491: 100.00
+	Hs
		1303503 PSB7_HUMAN (51-253): 3.22e-70: 219: 18.23		UCHL5_HUMAN (1-329): 1.1e-175: 491: 100.00
+	Hs
		656802 PSB5_HUMAN (11-252): 1.96e-70: 218: 21.07		UCHL5_HUMAN (1-329): 1.1e-175: 491: 100.00
+	Hs
		594671 PSB1_HUMAN (26-246): 7.33e-70: 217: 22.61		UCHL5_HUMAN (1-329): 1.1e-175: 491: 100.00
+	Sp
		1358105 PSA5_SCHPO (26-260): 2.06e-80: 243: 13.20		UBLH2_SCHPO (7-325): 1.13e-114: 335: 38.77
+	Sp
		675394 PSB5_SCHPO (22-263): 5.14e-80: 243: 21.81		UBLH2_SCHPO (7-325): 1.13e-114: 335: 38.77
+	Sp
		1000002 PSB2_SCHPO (46-264): 2.87e-72: 224: 17.81		UBLH2_SCHPO (7-325): 1.13e-114: 335: 38.77
+	Sp
		1358018 PSB7_SCHPO (7-263): 1.42e-72: 224: 38.31		UBLH2_SCHPO (7-325): 1.13e-114: 335: 38.77
+	Hs
		456530 PSA6_HUMAN (26-261): 3.03e-74: 228: 11.69		UCHL1_HUMAN (10-226): 1.03e-74: 231: 22.22
+	Sp
		195134 PSB1_SCHPO (53-243): 1.46e-22: 94.4: 18.75		UBLH2_SCHPO (7-325): 1.13e-114: 335: 38.77
+	Hs
		656510 PSB4_HUMAN (1-264): 6.75e-82: 248: 100.00		BAP1_HUMAN (246-315): 2.11e-16: 82: 34.29
+	Hs
		656282 PSA5_HUMAN (26-252): 6.98e-77: 234: 13.69		BAP1_HUMAN (246-315): 2.11e-16: 82: 34.29
+	Hs
		156332 PSA7_HUMAN (33-255): 6.14e-76: 232: 14.16		BAP1_HUMAN (246-315): 2.11e-16: 82: 34.29
+	Hs
		637724 PSA2_HUMAN (28-258): 1.95e-74: 228: 14.23		BAP1_HUMAN (246-315): 2.11e-16: 82: 34.29
+	Hs
		893717 PSA6_HUMAN (26-261): 3.03e-74: 228: 11.69		BAP1_HUMAN (246-315): 2.11e-16: 82: 34.29
+	Hs
		1267103 PSB7_HUMAN (51-253): 3.22e-70: 219: 18.23		BAP1_HUMAN (246-315): 2.11e-16: 82: 34.29
+	Hs
		594598 PSB1_HUMAN (26-246): 7.33e-70: 217: 22.61		BAP1_HUMAN (246-315): 2.11e-16: 82: 34.29