HitPredict

Interactor 1: 5HT2C (P28335)
5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C)
Gene: HTR2C

Interactor 2: CERS2 (Q96G23)
Ceramide synthase 2 (CerS2) (LAG1 longevity assurance homolog 2) (SP260) (Sphingosine N-acyltransferase CERS2) (EC 2.3.1.24) (Tumor metastasis-suppressor gene 1 protein) (Very-long-chain ceramide synthase CERS2) (EC 2.3.1.297)
Gene: CERS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.50	0.574

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 458 Hs			1 380
+	Hs
		658260 5HT2C_HUMAN (1-458): 1.97e-103: 317: 100.00		CERS5_HUMAN (2-340): 8.78e-143: 412: 44.58
+	Hs
		658250 5HT2C_HUMAN (1-458): 1.97e-103: 317: 100.00		CERS6_HUMAN (8-340): 1.88e-141: 409: 44.31
+	Hs
		656968 5HT1B_HUMAN (16-387): 2.6e-70: 229: 25.20		CERS2_HUMAN (1-380): 6.94e-161: 457: 100.00
+	Hs
		666327 NK3R_HUMAN (29-450): 3.42e-68: 226: 18.18		CERS5_HUMAN (2-340): 8.78e-143: 412: 44.58
+	Hs
		537300 DRD2_HUMAN (306-385): 7.12e-15: 78.2: 47.50		CERS2_HUMAN (1-380): 6.94e-161: 457: 100.00
+	Hs
		649189 5HT4R_HUMAN (35-441): 8.36e-68: 223: 24.59		CERS1_HUMAN (107-368): 3.29e-63: 207: 28.16
+	Hs
		783797 5HT2B_HUMAN (27-401): 1.83e-70: 233: 44.96		TR1L1_HUMAN (121-337): 1.82e-45: 161: 19.28
+	Hs
		537256 DRD2_HUMAN (306-385): 7.12e-15: 78.2: 47.50		CERS1_HUMAN (107-368): 3.29e-63: 207: 28.16
+	Hs
		537283 DRD2_HUMAN (306-385): 7.12e-15: 78.2: 47.50		TRAM1_HUMAN (121-333): 2.77e-57: 192: 20.09