HitPredict

Interactor 1: 5HT2C (P28335)
5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C)
Gene: HTR2C

Interactor 2: RTN4 (Q9NQC3)
Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5)
Gene: RTN4

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.678

Property	Details
Experiments	28514442, 28298427, 33961781
Identification Methods	affinity chromatography technology, two hybrid, ubiquitin reconstruction, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0045202 - synapse
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 458 Hs			1 1192
+	Hs
		666351 NK3R_HUMAN (29-450): 3.42e-68: 226: 18.18		RTN4_HUMAN (1-1192): 3.85e-113: 383: 100.00
+	Hs
		537317 DRD2_HUMAN (306-385): 7.12e-15: 78.2: 47.50		RTN4_HUMAN (1-1192): 3.85e-113: 383: 100.00
+	Hs
		429058 ADRB2_HUMAN (22-457): 4.42e-78: 250: 23.70		RTN1_HUMAN (419-1192): 1e-50: 194: 23.36
+	Hs
		306975 DRD2_HUMAN (306-385): 7.12e-15: 78.2: 47.50		RTN3_HUMAN (269-1191): 7.4e-55: 210: 22.06
+	Hs
		537284 DRD2_HUMAN (306-385): 7.12e-15: 78.2: 47.50		RTN1_HUMAN (419-1192): 1e-50: 194: 23.36