HitPredict

Interactor 1: KCC2B (P28652)
Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)
Gene: Camk2b

Interactor 2: NEB2 (Q6R891)
Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)
Gene: Ppp1r9b

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.680

Property	Details
Experiments	30562941, 20124353, 28634551, 36417873
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0014069 - postsynaptic density GO:0030425 - dendrite
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 542 Mm			1 817
+	Rn
		192509 KCC2B_RAT (1-542): 0: 631: 99.82		NEB2_RAT (1-817): 2.42e-118: 379: 98.90
+	Rn
		192511 KCC2G_RAT (1-542): 0: 594: 83.58		NEB2_RAT (1-817): 2.42e-118: 379: 98.90
+	Mm
		1164026 KCC2G_MOUSE (1-542): 0: 596: 81.25		NEB2_MOUSE (1-817): 1.3e-116: 374: 100.00
+	Rn
		192513 KCC2D_RAT (1-542): 0: 584: 79.71		NEB2_RAT (1-817): 2.42e-118: 379: 98.90
+	Mm
		1161534 KCC2D_MOUSE (1-542): 1.44e-173: 501: 65.87		NEB2_MOUSE (1-817): 1.3e-116: 374: 100.00
+	Rn
		192510 KCC2A_RAT (3-538): 6.08e-166: 481: 64.55		NEB2_RAT (1-817): 2.42e-118: 379: 98.90
+	Mm
		515240 KCC2A_MOUSE (3-538): 6.08e-166: 481: 64.55		NEB2_MOUSE (1-817): 1.3e-116: 374: 100.00
+	Mm
		659457 KCC2B_MOUSE (1-542): 0: 635: 100.00		DLG4_MOUSE (381-806): 1.83e-31: 133: 11.04
+	Mm
		1131547 Q5SVI3_MOUSE (1-542): 0: 608: 95.39		DLG4_MOUSE (381-806): 1.83e-31: 133: 11.04
+	Mm
		659459 KCC2B_MOUSE (1-542): 0: 635: 100.00		INADL_MOUSE (475-595): 1.73e-11: 70.4: 21.95
+	Rn
		506740 KCC2A_RAT (3-538): 6.08e-166: 481: 64.55		DLG1_RAT (244-705): 1.52e-41: 165: 16.22
+	Hs
		1271040 KCC2A_HUMAN (3-538): 5.82e-166: 481: 64.55		DLG3_HUMAN (269-734): 1.64e-40: 162: 16.36
+	Rn
		506744 KCC2A_RAT (3-538): 6.08e-166: 481: 64.55		DLG3_RAT (224-734): 2.62e-39: 158: 16.04
+	Mm
		1143346 KCC2D_MOUSE (1-542): 1.44e-173: 501: 65.87		DLG4_MOUSE (381-806): 1.83e-31: 133: 11.04
+	Mm
		250629 KCC2D_MOUSE (1-542): 1.44e-173: 501: 65.87		LNX1_MOUSE (224-773): 2.22e-30: 130: 12.21
+	Hs
		1021591 KCC2A_HUMAN (3-538): 5.82e-166: 481: 64.55		DLG1_HUMAN (80-763): 3.75e-33: 139: 11.22
+	Mm
		515234 KCC2A_MOUSE (3-538): 6.08e-166: 481: 64.55		DLG4_MOUSE (381-806): 1.83e-31: 133: 11.04
+	Mm
		515236 KCC2A_MOUSE (3-538): 6.08e-166: 481: 64.55		INADL_MOUSE (475-595): 1.73e-11: 70.4: 21.95
+	Hs
		159200 CSKP_HUMAN (10-308): 5.16e-84: 281: 46.73		DLG1_HUMAN (80-763): 3.75e-33: 139: 11.22
+	Hs
		159190 CSKP_HUMAN (10-308): 5.16e-84: 281: 46.73		DLG4_HUMAN (438-714): 1.14e-29: 127: 16.03