HitPredict

Interactor 1: CXB2 (P29033)
Gap junction beta-2 protein (Connexin-26) (Cx26)
Gene: GJB2

Interactor 2: CXA8 (P48165)
Gap junction alpha-8 protein (Connexin-50) (Cx50) (Lens fiber protein MP70)
Gene: GJA8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Connexin~Connexin
Common GO terms	GO:0005243 - gap junction channel activity GO:0005886 - plasma membrane GO:0005922 - connexin complex GO:0007267 - cell-cell signaling GO:1990349 - gap junction-mediated intercellular transport
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 226 Hs			1 433
+	Hs
		661197 CXB2_HUMAN (1-226): 1.37e-126: 358: 100.00		CXA3_HUMAN (1-433): 0: 535: 44.37
+	Hs
		661148 CXB2_HUMAN (1-226): 1.37e-126: 358: 100.00		CXA5_HUMAN (1-433): 8.65e-164: 466: 43.45
+	Hs
		566948 CXA1_HUMAN (2-223): 1.34e-105: 311: 43.75		CXA5_HUMAN (1-433): 8.65e-164: 466: 43.45
+	Rn
		435243 CXB2_RAT (1-226): 5.35e-126: 357: 93.81		CXA1_RAT (1-343): 9.46e-123: 363: 39.77
+	Hs
		661144 CXB2_HUMAN (1-226): 1.37e-126: 358: 100.00		CXB2_HUMAN (3-240): 4.54e-123: 358: 51.46
+	Hs
		566966 CXA8_HUMAN (2-226): 1.61e-120: 350: 51.46		CXA1_HUMAN (1-343): 1.53e-122: 362: 39.48
+	Hs
		567354 CXA3_HUMAN (2-219): 3.79e-112: 329: 48.26		CXA1_HUMAN (1-343): 1.53e-122: 362: 39.48
+	Hs
		434815 CXB2_HUMAN (1-226): 1.37e-126: 358: 100.00		CXB1_HUMAN (3-290): 8.02e-111: 329: 40.61
+	Mm
		657011 CXB2_MOUSE (1-226): 2.71e-125: 355: 92.92		CXB3_MOUSE (3-238): 2.46e-110: 327: 39.92
+	Hs
		734430 CXA3_HUMAN (2-219): 3.79e-112: 329: 48.26		CXG1_HUMAN (4-366): 2.43e-117: 349: 32.23
+	Hs
		566913 CXA1_HUMAN (2-223): 1.34e-105: 311: 43.75		CXA1_HUMAN (1-343): 1.53e-122: 362: 39.48
+	Mm
		657010 CXB6_MOUSE (1-224): 2.46e-121: 346: 78.13		CXB3_MOUSE (3-238): 2.46e-110: 327: 39.92
+	Hs
		566949 CXA1_HUMAN (2-223): 1.34e-105: 311: 43.75		CXG1_HUMAN (4-366): 2.43e-117: 349: 32.23
+	Mm
		613301 CXA1_MOUSE (2-223): 7.11e-105: 309: 43.33		CXG1_MOUSE (4-259): 1.91e-115: 345: 39.72
+	Hs
		274164 CXA3_HUMAN (2-219): 3.79e-112: 329: 48.26		CXB3_HUMAN (3-238): 8.81e-105: 313: 40.34
+	Hs
		567163 CXA1_HUMAN (2-223): 1.34e-105: 311: 43.75		CXD3_HUMAN (1-238): 1.26e-95: 290: 40.34