HitPredict

Interactor 1: PTN4 (P29074)
Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (MEG) (PTPase-MEG1)
Gene: PTPN4

Interactor 2: NMDE1 (Q12879)
Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A)
Gene: GRIN2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.50	0.521

Property	Details
Experiments	10748123, 22000519
Identification Methods	affinity chromatography technology, x-ray crystallography
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 926 Hs			1 1464
+	Hs
		616915 PTPRB_HUMAN (334-925): 1.77e-123: 415: 23.64		NMDE2_HUMAN (4-1464): 0: 1550: 52.95
+	Mm
		963780 E41L3_MOUSE (20-658): 1.11e-135: 431: 27.78		NMDE2_MOUSE (4-1464): 0: 1534: 52.82
+	Hs
		617106 PTPRG_HUMAN (671-917): 8.47e-50: 193: 23.74		NMDE2_HUMAN (4-1464): 0: 1550: 52.95
+	Hs
		203180 PTN4_HUMAN (1-926): 0: 949: 100.00		GRID2_HUMAN (11-909): 2.16e-178: 560: 21.51
+	Mm
		1142979 PTN4_MOUSE (1-926): 0: 942: 94.71		GRID2_MOUSE (74-889): 4.17e-179: 562: 22.04
+	Rn
		585158 E41L1_RAT (12-647): 2.76e-145: 454: 28.00		GRIA1_RAT (13-878): 0: 688: 19.67
+	Hs
		786708 E41L1_HUMAN (12-647): 6.92e-145: 453: 27.85		GRIA1_HUMAN (13-911): 0: 688: 19.41
+	Hs
		816225 E41L1_HUMAN (12-647): 6.92e-145: 453: 27.85		GRIA4_HUMAN (14-863): 0: 668: 19.01
+	Rn
		585225 E41L1_RAT (12-647): 2.76e-145: 454: 28.00		GRIA4_RAT (14-863): 0: 665: 18.79
+	Hs
		204626 E41L2_HUMAN (17-665): 1.48e-130: 419: 28.12		GRIA1_HUMAN (13-911): 0: 688: 19.41
+	Hs
		816228 E41L3_HUMAN (21-682): 1.53e-132: 427: 27.22		GRIA4_HUMAN (14-863): 0: 668: 19.01
+	Hs
		505583 EPB41_HUMAN (8-562): 2.24e-133: 423: 30.21		GRIA4_HUMAN (14-863): 0: 668: 19.01
+	Hs
		616949 PTPRD_HUMAN (348-912): 2e-97: 338: 21.33		GRIK1_HUMAN (1-847): 0: 721: 19.56
+	Hs
		1060436 PTPRK_HUMAN (643-914): 1.01e-55: 212: 27.72		NMDE3_HUMAN (2-923): 0: 797: 55.28
+	Rn
		723631 Q66HJ7_RAT (639-912): 1.14e-95: 321: 33.45		NMDZ1_RAT (8-940): 0: 685: 23.30
+	Rn
		585176 PTPRF_RAT (554-912): 1.41e-93: 327: 28.57		GRIA2_RAT (11-873): 0: 661: 17.59
+	Hs
		984265 PTPRK_HUMAN (643-914): 1.01e-55: 212: 27.72		NMDZ1_HUMAN (8-940): 0: 680: 23.30
+	Mm
		69650 PTPRS_MOUSE (312-912): 3.79e-93: 326: 19.31		GRID2_MOUSE (74-889): 4.17e-179: 562: 22.04
+	Ce
		656940 PTP1_CAEEL (6-926): 0: 691: 37.17		GLR1_CAEEL (372-841): 4.77e-46: 182: 28.40