Interactor 1: IL4RA (P24394)
Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
Gene: IL4R
Interactor 2: IL13 (P35225)
Interleukin-13 (IL-13)
Gene: IL13
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.88 | 1.00 | 0.941 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 22952195, 11313257, 33961781, 7721786, 8910586, 18243101 |
| Identification Methods | pull down, affinity chromatography technology, biochemical, protein cross-linking with a bifunctional reagent, x-ray crystallography, anti tag coimmunoprecipitation |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | IL13~IL4Ra_N |
| Common GO terms | GO:0002639 - positive regulation of immunoglobulin production GO:0005576 - extracellular region GO:0006955 - immune response GO:0009897 - external side of plasma membrane GO:0043032 - positive regulation of macrophage activation and 2 others more... |
| Homologous interactions | 3 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
