HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.50	0.565

Property	Details
Experiments	33961781, 35384245
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 976 Hs			1 378
+	Hs
		1072507 EPHA7_HUMAN (4-974): 0: 1128: 50.30		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		872447 EPHA5_HUMAN (11-976): 0: 1127: 51.34		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		872655 EPHA4_HUMAN (1-976): 0: 1121: 50.25		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		665401 EPHA3_HUMAN (24-976): 0: 1111: 51.19		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1083031 EPHA6_HUMAN (9-973): 0: 1089: 47.51		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		665610 EPHB2_HUMAN (28-973): 0: 1089: 48.29		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		665480 EPHA8_HUMAN (28-975): 0: 1049: 46.72		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		872537 EPHB4_HUMAN (14-970): 0: 986: 44.99		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		600580 EPHA1_HUMAN (17-967): 0: 959: 49.38		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		171305 EPHB6_HUMAN (28-962): 0: 871: 37.66		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		537743 INSRR_HUMAN (287-911): 2.3e-146: 470: 27.55		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1018328 MERTK_HUMAN (270-900): 9.58e-146: 460: 23.90		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		674444 UFO_HUMAN (294-911): 1.98e-146: 459: 24.49		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		411399 INSR_HUMAN (281-933): 1.71e-136: 445: 24.85		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		435654 IGF1R_HUMAN (393-877): 8.17e-134: 437: 30.00		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		609305 FGFR3_HUMAN (381-889): 9.01e-137: 431: 24.65		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		442838 HCK_HUMAN (591-880): 1.46e-65: 231: 42.12		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		433785 LYN_HUMAN (607-879): 2.06e-64: 228: 42.91		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00