Protein: GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha (DNA damage-inducible transcript 1 protein) (DDIT-1)

Gene: GA45A, GADD45A
Organism: Homo sapiens
Interactions: 96
UniProt ID: P24522

Gene Ontology (top 5):
GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

665230

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

2

3

Small-scale

0.812

High

550845

PCNA
Proliferating cell nuclear antigen

10

4

Small-scale

0.759

High

443186

CDK1
Cyclin-dependent kinase 1

8

2

Small-scale

0.756

High

665238

CDN1A
Cyclin-dependent kinase inhibitor 1

5

2

Small-scale

0.716

High

665256

DCTN2
Dynactin subunit 2

4

1

High-throughput

0.694

High

665300

M3K4
Mitogen-activated protein kinase kinase kinase 4

3

2

Small-scale

0.672

High

665249

EF1A1
Elongation factor 1-alpha 1

3

1

Small-scale

0.671

High

665253

TLE1
Transducin-like enhancer protein 1

1

1

High-throughput

0.656

High

665294

DD19B
ATP-dependent RNA helicase DDX19B

1

0

High-throughput

0.656

High

275452

GA45B
Growth arrest and DNA damage-inducible protein GADD45 beta

1

3

Small-scale

0.618

High

332137

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

3

Small-scale

0.618

High

665297

FBW1A
F-box/WD repeat-containing protein 1A

1

1

Small-scale

0.618

High

665278

CNOT9
CCR4-NOT transcription complex subunit 9

2

3

High-throughput

0.606

High

665288

PARVG
Gamma-parvin

2

2

High-throughput

0.606

High

446656

NPM
Nucleophosmin

2

0

Small-scale

0.603

High

625762

RXRA
Retinoic acid receptor RXR-alpha

2

6

Small-scale

0.600

High

665296

CD11A
Cyclin-dependent kinase 11A

2

5

Small-scale

0.586

High

665276

G45IP
Large ribosomal subunit protein mL64

1

2

Small-scale

0.586

High

169954

AURKA
Aurora kinase A

2

0

Small-scale

0.577

High

413209

P53
Cellular tumor antigen p53

2

0

Small-scale

0.575

High

665298

SHLB1
Endophilin-B1

1

2

High-throughput

0.573

High

665236

ERCC5
DNA excision repair protein ERCC-5

1

0

Small-scale

0.537

High

665240

MTOR
Serine/threonine-protein kinase mTOR

1

0

Small-scale

0.537

High

665252

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.537

High

665263

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

1

High-throughput

0.536

High

665267

SETX
Probable helicase senataxin

1

1

High-throughput

0.536

High

665231

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.518

High

665283

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

0

High-throughput

0.518

High

665257

TDG
G/T mismatch-specific thymine DNA glycosylase

1

1

Small-scale

0.515

High

129655

CBX4
E3 SUMO-protein ligase CBX4

1

0

High-throughput

0.513

High

665271

ZZZ3
ZZ-type zinc finger-containing protein 3

1

0

High-throughput

0.513

High

665287

CSR2B
Cysteine-rich protein 2-binding protein

1

0

High-throughput

0.513

High

665289

KBRS2
NF-kappa-B inhibitor-interacting Ras-like protein 2

1

0

High-throughput

0.513

High

665293

PALD
Paladin

1

0

High-throughput

0.513

High

665299

PUS1
Pseudouridylate synthase 1 homolog

1

0

High-throughput

0.513

High

665233

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.508

High

665243

MASP1
Mannan-binding lectin serine protease 1

1

2

High-throughput

0.508

High

665262

MIDN
Midnolin

1

1

High-throughput

0.508

High

665277

MICA1
[F-actin]-monooxygenase MICAL1

1

2

High-throughput

0.508

High

665284

SPTN4
Spectrin beta chain, non-erythrocytic 4

1

1

High-throughput

0.508

High

573750

CCNB1
G2/mitotic-specific cyclin-B1

1

2

Small-scale

0.501

High

665282

AICDA
Single-stranded DNA cytosine deaminase

1

1

Small-scale

0.500

High

665279

KLK6
Kallikrein-6

1

0

High-throughput

0.493

High

665272

TRM2A
tRNA

1

1

High-throughput

0.489

High

665286

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

1

High-throughput

0.489

High

291010

ADAP1
Arf-GAP with dual PH domain-containing protein 1

1

0

High-throughput

0.486

High

408677

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.486

High

430716

TETN
Tetranectin

1

0

High-throughput

0.486

High

451483

CENPB
Major centromere autoantigen B

1

0

High-throughput

0.486

High

474486

VIME
Vimentin

1

0

High-throughput

0.486

High

586526

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.486

High

665237

GBP2
Guanylate-binding protein 2

1

0

High-throughput

0.486

High

665242

SYQ
Glutamine--tRNA ligase

1

0

High-throughput

0.486

High

665244

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

0

High-throughput

0.486

High

665245

ZN135
Zinc finger protein 135

1

0

High-throughput

0.486

High

665246

LMO4
LIM domain transcription factor LMO4

1

0

High-throughput

0.486

High

665248

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.486

High

665254

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.486

High

665255

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.486

High

665260

JHD2C
Probable JmjC domain-containing histone demethylation protein 2C

1

0

High-throughput

0.486

High

665268

RAI1
Retinoic acid-induced protein 1

1

0

High-throughput

0.486

High

665269

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.486

High

665280

FUBP2
Far upstream element-binding protein 2

1

0

High-throughput

0.486

High

665285

FA83D
Protein FAM83D

1

0

High-throughput

0.486

High

665290

NRBP
Nuclear receptor-binding protein

1

0

High-throughput

0.486

High

665292

ZHX1
Zinc fingers and homeoboxes protein 1

1

0

High-throughput

0.486

High

395507

ESR1
Estrogen receptor

1

7

Small-scale

0.479

High

520513

RARA
Retinoic acid receptor alpha

1

9

Small-scale

0.479

High

665234

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

Small-scale

0.479

High

665239

STAT3
Signal transducer and activator of transcription 3

1

1

Small-scale

0.479

High

665270

CDAN1
Codanin-1

1

1

Small-scale

0.479

High

636704

PTN
Pleiotrophin

1

1

High-throughput

0.464

High

610226

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.460

High

665241

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.460

High

484925

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

665232

DNMT1
DNA

1

0

Small-scale

0.458

High

665235

MK01
Mitogen-activated protein kinase 1

1

0

Small-scale

0.458

High

665247

RS7
Small ribosomal subunit protein eS7

1

0

Small-scale

0.458

High

665295

ING4
Inhibitor of growth protein 4

1

0

Small-scale

0.458

High

665259

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

1

High-throughput

0.439

High

391187

FRIL
Ferritin light chain

1

0

High-throughput

0.438

High

665265

CREL2
Protein disulfide isomerase CRELD2

1

1

High-throughput

0.417

High

665250

NUCB2
Nucleobindin-2

1

0

High-throughput

0.299

High

665274

LNX2
Ligand of Numb protein X 2

1

0

High-throughput

0.292

High

665275

CBY2
Protein chibby homolog 2

1

0

High-throughput

0.292

High

665264

PR14L
Protein PRR14L

1

0

High-throughput

0.279

Low

665258

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.268

Low

273488

DJC13
DnaJ homolog subfamily C member 13

1

0

High-throughput

0.265

Low

665251

EM55
55 kDa erythrocyte membrane protein

1

0

High-throughput

0.265

Low

665261

F264
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

1

0

High-throughput

0.265

Low

665266

FBN3
Fibrillin-3 [Cleaved into: Fibrillin-3 C-terminal peptide]

1

0

High-throughput

0.265

Low

665273

SYNE4
Nesprin-4

1

0

High-throughput

0.265

Low

665281

IGS21
Immunoglobulin superfamily member 21

1

0

High-throughput

0.265

Low

665291

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.265

Low

379489

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025