HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: RHOU (Q7L0Q8)
Rho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)
Gene: RHOU

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 258
+	Hs
		436169 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96
+	Hs
		665313 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOV_HUMAN (49-258): 3.82e-87: 260: 60.66
+	Hs
		436317 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96
+	Hs
		665191 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		665208 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93
+	Hs
		1072530 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOU_HUMAN (1-258): 1.4e-83: 252: 100.00
+	Hs
		665201 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		892388 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		665197 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RB11A_HUMAN (39-256): 1.13e-77: 235: 26.87
+	Hs
		951011 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93
+	Hs
		665194 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		545218 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52
+	Hs
		665192 EPHA2_HUMAN (1-976): 0: 1141: 100.00		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Hs
		925297 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		900497 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		545394 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52
+	Hs
		564420 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOQ_HUMAN (50-221): 2.69e-66: 206: 56.40
+	Hs
		665332 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOJ_HUMAN (40-238): 2.64e-63: 199: 51.26
+	Hs
		564541 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOQ_HUMAN (50-221): 2.69e-66: 206: 56.40
+	Hs
		1072595 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOJ_HUMAN (40-238): 2.64e-63: 199: 51.26