HitPredict

Interactor 1: EPHA3 (P29320)
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
Gene: EPHA3

Interactor 2: NISCH (Q9Y2I1)
Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein)
Gene: NISCH

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005769 - early endosome GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 983 Hs			1 1504
+	Hs
		872509 EPHA5_HUMAN (7-983): 0: 1202: 65.97		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		1072633 EPHA7_HUMAN (6-979): 0: 1198: 61.46		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		665686 EPHB2_HUMAN (29-981): 0: 1167: 55.90		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		872733 EPHA4_HUMAN (8-983): 0: 1164: 62.40		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		665544 EPHA8_HUMAN (29-982): 0: 1099: 56.57		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		665370 EPHA2_HUMAN (27-983): 0: 1061: 50.47		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		665407 EPHA3_HUMAN (1-983): 0: 1248: 100.00		LRC49_HUMAN (190-453): 3.87e-30: 130: 20.60
+	Hs
		1049958 EPHA7_HUMAN (6-979): 0: 1198: 61.46		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01
+	Hs
		665600 EPHB2_HUMAN (29-981): 0: 1167: 55.90		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01
+	Hs
		665495 EPHA8_HUMAN (29-982): 0: 1099: 56.57		LRC49_HUMAN (190-453): 3.87e-30: 130: 20.60
+	At
		83731 Y5182_ARATH (329-915): 1.36e-152: 475: 16.89		Q9XGZ2_ARATH (2-714): 1.79e-90: 319: 12.05
+	At
		83704 Y5182_ARATH (329-915): 1.36e-152: 475: 16.89		Y4361_ARATH (174-666): 4.68e-69: 256: 12.80
+	At
		83725 Y5182_ARATH (329-915): 1.36e-152: 475: 16.89		MIK1_ARATH (115-609): 7.79e-51: 198: 15.95
+	At
		83721 Y5182_ARATH (329-915): 1.36e-152: 475: 16.89		Y3804_ARATH (260-586): 2.14e-38: 158: 19.35
+	Hs
		537756 INSRR_HUMAN (295-918): 5.63e-141: 455: 24.85		LRC49_HUMAN (190-453): 3.87e-30: 130: 20.60
+	Hs
		674422 UFO_HUMAN (265-962): 1.06e-153: 479: 22.82		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01
+	At
		83729 Y5182_ARATH (329-915): 1.36e-152: 475: 16.89		CLV1_ARATH (3-154): 2.61e-16: 87: 6.63
+	At
		83702 Y5182_ARATH (329-915): 1.36e-152: 475: 16.89		RGI3_ARATH (406-666): 4.94e-16: 86.3: 10.19
+	At
		83724 Y5182_ARATH (329-915): 1.36e-152: 475: 16.89		PXC2_ARATH (333-564): 1.22e-12: 75.1: 17.09
+	Hs
		435639 IGF1R_HUMAN (366-883): 1.6e-139: 453: 30.02		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01