HitPredict

Interactor 1: EPHB2 (P29323)
Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
Gene: EPHB2

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1055 Hs			1 665
+	Hs
		665574 EPHB2_HUMAN (20-1055): 0: 1304: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		665608 EPHB2_HUMAN (20-1055): 0: 1304: 100.00		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Mm
		872621 EPHB2_MOUSE (1-985): 0: 1254: 99.49		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		557644 EPHB1_HUMAN (20-985): 0: 1211: 73.60		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		872610 EPHB1_HUMAN (20-985): 0: 1211: 73.60		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		171320 EPHB6_HUMAN (20-985): 0: 927: 46.28		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		924590 EPHA7_HUMAN (6-982): 0: 1154: 57.46		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		665389 EPHA3_HUMAN (16-980): 0: 1152: 56.37		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		872630 EPHA4_HUMAN (6-982): 0: 1152: 58.33		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		557643 EPHA5_HUMAN (6-984): 0: 1148: 56.69		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		872422 EPHA5_HUMAN (6-984): 0: 1148: 56.69		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		209018 EPHA4_HUMAN (6-982): 0: 1152: 58.33		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Hs
		665467 EPHA8_HUMAN (20-982): 0: 1066: 50.71		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		665200 EPHA2_HUMAN (18-980): 0: 1041: 47.98		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		208997 EPHA8_HUMAN (20-982): 0: 1066: 50.71		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Hs
		208996 EPHA2_HUMAN (18-980): 0: 1041: 47.98		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Hs
		600548 EPHA1_HUMAN (12-976): 0: 961: 41.21		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		171284 EPHB6_HUMAN (20-985): 0: 927: 46.28		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		411352 INSR_HUMAN (277-941): 5.94e-150: 484: 24.02		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		411288 INSR_HUMAN (277-941): 5.94e-150: 484: 24.02		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95