HitPredict

Interactor 1: EPHB2 (P29323)
Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
Gene: EPHB2

Interactor 2: PKHA5 (Q9HAU0)
Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)
Gene: PLEKHA5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1055 Hs			1 1116
+	Hs
		1072602 EPHA7_HUMAN (6-982): 0: 1154: 57.46		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		872491 EPHA5_HUMAN (6-984): 0: 1148: 56.69		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		600673 EPHA1_HUMAN (12-976): 0: 961: 41.21		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		171334 EPHB6_HUMAN (20-985): 0: 927: 46.28		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		665662 EPHB2_HUMAN (20-1055): 0: 1304: 100.00		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		872669 EPHA4_HUMAN (6-982): 0: 1152: 58.33		MAGI2_HUMAN (4-650): 6.29e-50: 195: 11.18
+	Hs
		1072603 EPHA7_HUMAN (6-982): 0: 1154: 57.46		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		872712 EPHA4_HUMAN (6-982): 0: 1152: 58.33		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		872492 EPHA5_HUMAN (6-984): 0: 1148: 56.69		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		600712 EPHA1_HUMAN (12-976): 0: 961: 41.21		PKHA6_HUMAN (109-1116): 8.74e-73: 264: 28.52
+	Hs
		665271 EPHA2_HUMAN (18-980): 0: 1041: 47.98		MPRIP_HUMAN (95-395): 8.25e-38: 155: 13.86
+	Hs
		171335 EPHB6_HUMAN (20-985): 0: 927: 46.28		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		435765 IGF1R_HUMAN (347-885): 2.31e-146: 474: 27.31		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		600632 EPHA1_HUMAN (12-976): 0: 961: 41.21		TITIN_HUMAN (275-1090): 3.45e-10: 67: 9.15
+	Hs
		411498 INSR_HUMAN (277-941): 5.94e-150: 484: 24.02		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		674531 UFO_HUMAN (266-950): 2.71e-152: 477: 23.12		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Rn
		94019 INSR_RAT (280-937): 2.81e-145: 471: 24.56		F1LLX6_RAT (70-775): 8.96e-41: 165: 11.16
+	Hs
		435768 IGF1R_HUMAN (347-885): 2.31e-146: 474: 27.31		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		601535 FGFR2_HUMAN (392-932): 6.72e-145: 455: 22.69		MPRIP_HUMAN (95-395): 8.25e-38: 155: 13.86
+	Hs
		674522 UFO_HUMAN (266-950): 2.71e-152: 477: 23.12		WWP1_HUMAN (3-240): 7.83e-24: 110: 14.94