HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: FCG2B (P31994)
Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)
Gene: FCGR2B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	8940017, 10382761
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 310
+	Hs
		442905 SHC1_HUMAN (1-583): 0: 531: 100.00		FCG3A_HUMAN (38-272): 1.15e-50: 169: 36.93
+	Mm
		722900 SHC1_MOUSE (1-583): 0: 527: 94.51		CD22_MOUSE (3-308): 2.01e-25: 108: 14.96
+	Hs
		519324 SHC1_HUMAN (1-583): 0: 531: 100.00		FCGR1_HUMAN (5-285): 9.76e-21: 92.9: 12.25
+	Hs
		532362 SHC1_HUMAN (1-583): 0: 531: 100.00		CEAM1_HUMAN (19-298): 1.53e-16: 81.8: 13.15
+	Hs
		590602 SHC1_HUMAN (1-583): 0: 531: 100.00		CD22_HUMAN (92-310): 1.59e-09: 60.9: 13.33
+	Hs
		770275 SHC3_HUMAN (6-582): 3.32e-127: 387: 45.47		CEAM6_HUMAN (42-245): 4.21e-14: 73.7: 27.80
+	Hs
		557621 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		FCG2B_HUMAN (1-310): 7.03e-74: 231: 100.00
+	Hs
		557622 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		FCG2C_HUMAN (1-310): 1.99e-62: 202: 83.92
+	Hs
		519366 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		FCG2A_HUMAN (38-310): 3.57e-58: 191: 73.29
+	Mm
		524116 ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86		CNTN1_MOUSE (50-310): 1.58e-29: 120: 13.15
+	Hs
		519376 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		FCG2A_HUMAN (38-310): 3.57e-58: 191: 73.29
+	Mm
		936320 ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86		DCC_MOUSE (123-301): 9.01e-20: 91.8: 12.75
+	Mm
		435878 HCK_MOUSE (348-582): 2.92e-40: 155: 19.11		FCGR1_MOUSE (5-304): 1.63e-24: 104: 16.09
+	Mm
		643060 P85A_MOUSE (300-581): 6.66e-38: 151: 15.99		CD22_MOUSE (3-308): 2.01e-25: 108: 14.96
+	Hs
		442771 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		FCGR1_HUMAN (5-285): 9.76e-21: 92.9: 12.25
+	Hs
		209143 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		FCRL2_HUMAN (52-217): 1.22e-13: 72.9: 19.89
+	Hs
		855816 VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97		TITIN_HUMAN (100-243): 6.17e-09: 59.4: 12.42
+	Hs
		557704 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		MYLK_HUMAN (49-129): 7.38e-12: 68.3: 13.83
+	Hs
		655385 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		MYLK_HUMAN (49-129): 7.38e-12: 68.3: 13.83
+	Hs
		590600 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		CD22_HUMAN (92-310): 1.59e-09: 60.9: 13.33