HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: SNX27 (Q96L92)
Sorting nexin-27
Gene: SNX27

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34315543
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~PID
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 541
+	Mm
		1112561 ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86		SNX27_MOUSE (1-541): 0: 621: 98.52
+	Hs
		1268489 ANS1A_HUMAN (40-393): 2.28e-42: 165: 18.41		SNX27_HUMAN (1-541): 0: 625: 100.00
+	Hs
		666158 SHC1_HUMAN (1-583): 0: 531: 100.00		NEB2_HUMAN (40-314): 3.95e-34: 139: 17.98
+	Hs
		557697 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		SNX17_HUMAN (162-535): 9.12e-108: 331: 25.31
+	Hs
		655373 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		SNX17_HUMAN (162-535): 9.12e-108: 331: 25.31
+	Hs
		924584 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		SNX17_HUMAN (162-535): 9.12e-108: 331: 25.31
+	Hs
		1287792 Q96D37_HUMAN (163-578): 1.11e-54: 200: 12.25		NEB2_HUMAN (40-314): 3.95e-34: 139: 17.98
+	Hs
		548744 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		NEB2_HUMAN (40-314): 3.95e-34: 139: 17.98
+	Hs
		548755 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		LIN7C_HUMAN (35-136): 1.5e-27: 111: 34.95
+	Rn
		192767 APBA2_RAT (17-330): 3.94e-43: 166: 15.27		GRASP_RAT (7-172): 5.89e-30: 123: 24.86
+	Hs
		557831 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		SHAN2_HUMAN (43-147): 7.14e-29: 124: 38.10
+	Hs
		655508 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		SHAN2_HUMAN (43-147): 7.14e-29: 124: 38.10
+	Mm
		1116002 ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86		SHAN3_MOUSE (44-148): 2.57e-21: 100: 36.19
+	Hs
		557787 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		SHAN3_HUMAN (44-148): 1.57e-21: 101: 37.14
+	Hs
		655457 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		SHAN3_HUMAN (44-148): 1.57e-21: 101: 37.14
+	Hs
		924806 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		NEB2_HUMAN (40-314): 3.95e-34: 139: 17.98
+	Hs
		924955 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		SHAN2_HUMAN (43-147): 7.14e-29: 124: 38.10
+	Hs
		924545 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		SNTA1_HUMAN (1-188): 2.48e-29: 123: 20.10
+	Hs
		924841 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		SHAN3_HUMAN (44-148): 1.57e-21: 101: 37.14
+	Mm
		1115913 GRB2_MOUSE (482-578): 3.54e-15: 76.8: 30.48		SHAN3_MOUSE (44-148): 2.57e-21: 100: 36.19