Protein: PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2 (PDEase 2) (EC 3.1.4.53) (High-affinity cAMP phosphodiesterase)

Gene: PDE2
Organism: Saccharomyces cerevisiae S288C
Interactions: 86
UniProt ID: P06776

Gene Ontology (top 5):
GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0019933 - cAMP-mediated signaling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

419433

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

7

High-throughput

0.618

High

419484

NNF1
Kinetochore-associated protein NNF1

1

0

High-throughput

0.518

High

419459

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

1

High-throughput

0.515

High

419485

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

1

High-throughput

0.515

High

419486

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

1

High-throughput

0.515

High

419468

LHS1
Heat shock protein 70 homolog LHS1

1

2

High-throughput

0.494

High

355298

H2B1
Histone H2B.1

1

2

High-throughput

0.479

High

355736

H2B2
Histone H2B.2

1

2

High-throughput

0.479

High

392016

H2A1
Histone H2A.1

1

1

High-throughput

0.479

High

392242

H2A2
Histone H2A.2

1

1

High-throughput

0.479

High

419439

NHP6A
Non-histone chromosomal protein 6A

1

2

High-throughput

0.479

High

419440

NHP6B
Non-histone chromosomal protein 6B

1

2

High-throughput

0.479

High

419449

RCC1
Guanine nucleotide exchange factor SRM1

1

2

High-throughput

0.479

High

419475

RCK2
Serine/threonine-protein kinase RCK2

1

6

High-throughput

0.479

High

419497

ABF2
ARS-binding factor 2, mitochondrial

1

3

High-throughput

0.479

High

419500

HMO1
High mobility group protein 1

1

3

High-throughput

0.479

High

419510

H2AZ
Histone H2A.Z

1

2

High-throughput

0.479

High

356164

H4
Histone H4

1

0

High-throughput

0.458

High

419434

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.458

High

419435

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.458

High

419441

RAP1
DNA-binding protein RAP1

1

0

High-throughput

0.458

High

419442

TBP
TATA-box-binding protein

1

0

High-throughput

0.458

High

419443

ABF1
ARS-binding factor 1

1

0

High-throughput

0.458

High

419445

RPC7
DNA-directed RNA polymerase III subunit RPC7

1

0

High-throughput

0.458

High

419446

GLN3
Nitrogen regulatory protein GLN3

1

0

High-throughput

0.458

High

419447

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

419448

ACE2
Metallothionein expression activator

1

0

High-throughput

0.458

High

419450

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

419451

RFA1
Replication factor A protein 1

1

0

High-throughput

0.458

High

419452

RL24B
Large ribosomal subunit protein eL24B

1

0

High-throughput

0.458

High

419453

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.458

High

419454

RSC6
Chromatin structure-remodeling complex protein RSC6

1

0

High-throughput

0.458

High

419455

MIG1
Regulatory protein MIG1

1

0

High-throughput

0.458

High

419456

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.458

High

419458

IMB3
Importin subunit beta-3

1

0

High-throughput

0.458

High

419461

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

0

High-throughput

0.458

High

419463

IES6
Chromatin-remodeling complex subunit IES6

1

0

High-throughput

0.458

High

419464

T2AG
Transcription initiation factor IIA subunit 2

1

0

High-throughput

0.458

High

419465

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

0

High-throughput

0.458

High

419466

MSN2
Zinc finger protein MSN2

1

0

High-throughput

0.458

High

419467

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

419469

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

0

High-throughput

0.458

High

419470

KAE1
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.458

High

419471

NOP4
Nucleolar protein 4

1

0

High-throughput

0.458

High

419473

SWC5
SWR1-complex protein 5

1

0

High-throughput

0.458

High

419474

RGD1
RHO GTPase-activating protein RGD1

1

0

High-throughput

0.458

High

419477

NOP16
Nucleolar protein 16

1

0

High-throughput

0.458

High

419479

IES2
Ino eighty subunit 2

1

0

High-throughput

0.458

High

419480

ATAD2
ATPase histone chaperone YTA7

1

0

High-throughput

0.458

High

419481

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

419483

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.458

High

419487

RPA14
DNA-directed RNA polymerase I subunit RPA14

1

0

High-throughput

0.458

High

419488

RT102
Regulator of Ty1 transposition protein 102

1

0

High-throughput

0.458

High

419489

H1
Histone H1

1

0

High-throughput

0.458

High

419490

CRZ1
Transcriptional regulator CRZ1

1

0

High-throughput

0.458

High

419491

SUB1
RNA polymerase II transcriptional coactivator SUB1

1

0

High-throughput

0.458

High

419492

MOT3
Transcriptional activator/repressor MOT3

1

0

High-throughput

0.458

High

419493

H3
Histone H3

1

0

High-throughput

0.458

High

419494

DID2
Vacuolar protein-sorting-associated protein 46

1

0

High-throughput

0.458

High

419495

HPC2
Histone promoter control protein 2

1

0

High-throughput

0.458

High

419496

CIK1
Spindle pole body-associated protein CIK1

1

0

High-throughput

0.458

High

419498

DIG1
Down-regulator of invasive growth 1

1

0

High-throughput

0.458

High

419502

DPB4
DNA polymerase epsilon subunit D

1

0

High-throughput

0.458

High

419503

ECM22
Sterol regulatory element-binding protein ECM22

1

0

High-throughput

0.458

High

419504

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.458

High

419505

RSC3
Chromatin structure-remodeling complex protein RSC3

1

0

High-throughput

0.458

High

419509

IES4
Ino eighty subunit 4

1

0

High-throughput

0.458

High

419511

HAA1
Transcriptional activator HAA1

1

0

High-throughput

0.458

High

419436

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

419437

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

419438

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

419478

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

419499

NSE5
Non-structural maintenance of chromosome element 5

1

0

High-throughput

0.438

High

419444

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.249

Low

419457

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

0

High-throughput

0.249

Low

419460

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

0

High-throughput

0.249

Low

419462

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

419472

LDB7
Chromatin structure-remodeling complex protein RSC14

1

0

High-throughput

0.249

Low

419476

CIC1
Proteasome-interacting protein CIC1

1

0

High-throughput

0.249

Low

419482

NET1
Nucleolar protein NET1

1

0

High-throughput

0.249

Low

419501

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.249

Low

419506

NOP6
Nucleolar protein 6

1

0

High-throughput

0.249

Low

419507

NOP12
Nucleolar protein 12

1

0

High-throughput

0.249

Low

419508

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.249

Low

419512

NOP10
H/ACA ribonucleoprotein complex subunit NOP10

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024