Protein: MEK1
Meiosis-specific serine/threonine-protein kinase MEK1 (EC 2.7.11.1)

Gene: MEK1
Organism: Saccharomyces cerevisiae S288C
Interactions: 115
UniProt ID: P24719

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

666146

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

4

17

Small-scale

0.899

High

666162

RAD54
DNA repair and recombination protein RAD54

3

2

Small-scale

0.664

High

441333

KAPB
cAMP-dependent protein kinase type 2

1

14

High-throughput

0.647

High

454706

KAPR
cAMP-dependent protein kinase regulatory subunit

1

13

High-throughput

0.647

High

666177

RIM4
Meiotic activator RIM4

1

3

High-throughput

0.647

High

666200

DOHH
Deoxyhypusine hydroxylase

1

1

High-throughput

0.647

High

448645

SNF1
Carbon catabolite-derepressing protein kinase

1

9

High-throughput

0.646

High

578894

HSC82
ATP-dependent molecular chaperone HSC82

1

20

High-throughput

0.646

High

666151

MIG1
Regulatory protein MIG1

1

0

High-throughput

0.614

High

666207

PCL10
PHO85 cyclin-10

1

0

High-throughput

0.614

High

571305

RED1
Protein RED1

2

0

Small-scale

0.605

High

518215

IF4A
ATP-dependent RNA helicase eIF4A

2

3

High-throughput

0.602

High

627769

HOP1
Meiosis-specific protein HOP1

2

0

Small-scale

0.594

High

543890

SSB1
Ribosome-associated molecular chaperone SSB1

2

9

High-throughput

0.584

High

666181

NDT80
Meiosis-specific transcription factor NDT80

2

0

Small-scale

0.583

High

666184

TEM1
Protein TEM1

1

3

High-throughput

0.579

High

666150

GYS2
Glycogen [starch] synthase isoform 2

2

0

High-throughput

0.577

High

666147

SIS1
Protein SIS1

1

7

High-throughput

0.575

High

666148

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.575

High

666178

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.536

High

666193

ERR3
Enolase-related protein 3

1

5

High-throughput

0.536

High

666210

SLG1
Protein SLG1

1

0

Small-scale

0.529

High

666183

NMD3
60S ribosomal export protein NMD3

1

0

High-throughput

0.513

High

666179

RRM3
ATP-dependent DNA helicase RRM3

1

0

Small-scale

0.504

High

581924

CATA
Peroxisomal catalase A

1

1

High-throughput

0.501

High

598813

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

4

High-throughput

0.501

High

666155

MLF3
Protein MLF3

1

2

High-throughput

0.501

High

666156

GLNA
Glutamine synthetase

1

1

High-throughput

0.501

High

666161

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

2

High-throughput

0.501

High

666166

ATG19
Autophagy-related protein 19

1

2

High-throughput

0.501

High

666170

ALY1
Arrestin-related trafficking adapter 6

1

2

High-throughput

0.501

High

666171

ADCS
Aminodeoxychorismate synthase

1

2

High-throughput

0.501

High

666173

ATR
Serine/threonine-protein kinase MEC1

1

17

Small-scale

0.501

High

666185

UME6
Transcriptional regulatory protein UME6

1

1

High-throughput

0.501

High

666190

VHS2
Protein VHS2

1

2

High-throughput

0.501

High

666194

UAP1
UDP-N-acetylglucosamine pyrophosphorylase

1

1

High-throughput

0.501

High

666211

H3
Histone H3

1

10

Small-scale

0.501

High

666219

SML1
Ribonucleotide reductase inhibitor protein SML1

1

2

High-throughput

0.501

High

366939

ATPB
ATP synthase subunit beta, mitochondrial

1

4

High-throughput

0.500

High

367700

ENO1
Enolase 1

1

5

High-throughput

0.500

High

399344

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

1

High-throughput

0.500

High

416379

HXKA
Hexokinase-1

1

4

High-throughput

0.500

High

439254

PDC1
Pyruvate decarboxylase isozyme 1

1

2

High-throughput

0.500

High

453434

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.500

High

531249

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.500

High

550750

INO1
Inositol-3-phosphate synthase

1

2

High-throughput

0.500

High

592030

VATB
V-type proton ATPase subunit B

1

4

High-throughput

0.500

High

597045

BIP
Endoplasmic reticulum chaperone BiP

1

6

High-throughput

0.500

High

598959

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

4

High-throughput

0.500

High

626601

HSP60
Heat shock protein 60, mitochondrial

1

5

High-throughput

0.500

High

666149

CDC48
Cell division control protein 48

1

4

High-throughput

0.500

High

666152

URA7
CTP synthase 1

1

1

High-throughput

0.500

High

666153

BMH1
Protein BMH1

1

13

High-throughput

0.500

High

666176

YHI0
Putative proline--tRNA ligase YHR020W

1

1

High-throughput

0.500

High

666182

ARO9
Aromatic amino acid aminotransferase 2

1

2

High-throughput

0.500

High

666221

HSP42
Heat shock protein 42

1

2

High-throughput

0.500

High

557667

SRS2
ATP-dependent DNA helicase SRS2

1

1

Small-scale

0.481

High

666165

SGS1
ATP-dependent helicase SGS1

1

4

Small-scale

0.481

High

438255

NOT3
General negative regulator of transcription subunit 3

1

0

High-throughput

0.480

High

439559

LEU1
2-isopropylmalate synthase

1

0

High-throughput

0.480

High

598355

ATE1
Arginyl-tRNA--protein transferase 1

1

0

High-throughput

0.480

High

638027

UTR1
NAD(+) kinase

1

0

High-throughput

0.480

High

666154

MLS1
Malate synthase 1

1

0

High-throughput

0.480

High

666157

PAH1
Phosphatidic acid phosphohydrolase 1

1

0

High-throughput

0.480

High

666160

PEP7
Vacuolar segregation protein PEP7

1

0

High-throughput

0.480

High

666163

TYE7
Transcription factor TYE7

1

0

High-throughput

0.480

High

666164

ASH1
Transcriptional regulatory protein ASH1

1

0

High-throughput

0.480

High

666167

ASK1
DASH complex subunit ASK1

1

0

High-throughput

0.480

High

666169

RCN1
Calcipressin-like protein

1

0

High-throughput

0.480

High

666172

SOL2
6-phosphogluconolactonase-like protein 2

1

0

High-throughput

0.480

High

666175

YHJ3
Uncharacterized protein YHR033W

1

0

High-throughput

0.480

High

666189

SIP5
Protein SIP5

1

0

High-throughput

0.480

High

666191

SYA
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.480

High

666192

BUD6
Bud site selection protein 6

1

0

High-throughput

0.480

High

666196

BUD27
Bud site selection protein 27

1

0

High-throughput

0.480

High

666197

WWM1
WW domain-containing protein WWM1

1

0

High-throughput

0.480

High

666198

IDS2
IME2-dependent-signaling protein

1

0

High-throughput

0.480

High

666201

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.480

High

666204

YJ9S
Uncharacterized protein YJR154W

1

0

High-throughput

0.480

High

666205

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.480

High

666208

EFM5
Protein-lysine N-methyltransferase EFM5

1

0

High-throughput

0.480

High

666217

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.480

High

394260

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.479

High

471372

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.479

High

666187

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.479

High

666174

MMS4
Crossover junction endonuclease MMS4

1

0

Small-scale

0.460

High

666202

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

666216

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.458

High

666186

HPH2
Protein HPH2

1

1

High-throughput

0.457

High

666206

MALX3
Oligo-1,6-glucosidase IMA1

1

1

High-throughput

0.457

High

666213

ATG21
Autophagy-related protein 21

1

1

High-throughput

0.457

High

666215

ARA2
D-arabinose 1-dehydrogenase

1

3

High-throughput

0.457

High

405036

LEU3
3-isopropylmalate dehydrogenase

1

4

High-throughput

0.457

High

408555

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

2

High-throughput

0.457

High

456336

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

2

High-throughput

0.457

High

555012

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.457

High

575388

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

1

High-throughput

0.457

High

644716

CLH
Clathrin heavy chain

1

1

High-throughput

0.457

High

510222

HSP77
Import motor subunit, mitochondrial

1

8

High-throughput

0.445

High

523128

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.445

High

666158

HSP7F
Heat shock protein homolog SSE1

1

11

High-throughput

0.445

High

666180

SSZ1
Ribosome-associated complex subunit SSZ1

1

5

High-throughput

0.445

High

666188

SSB2
Ribosome-associated molecular chaperone SSB2

1

9

High-throughput

0.445

High

666199

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.445

High

666168

MID2
Cell wall integrity sensor MID2

1

2

Small-scale

0.439

High

666212

YP077
Uncharacterized protein YPL077C

2

0

High-throughput

0.314

High

659152

MBR1
Mitochondrial biogenesis regulation protein 1

1

0

High-throughput

0.261

Low

666159

SEC17
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.261

Low

666195

MIL1
Probable lipase MIL1

1

0

High-throughput

0.261

Low

666203

ENT3
Epsin-3

1

0

High-throughput

0.261

Low

666209

YN93
Uncharacterized hydrolase YNR064C

1

0

High-throughput

0.261

Low

666214

HED1
Meiosis-specific protein HED1

1

0

Small-scale

0.261

Low

666220

FRE8
Probable ferric reductase transmembrane component 8

1

0

High-throughput

0.261

Low

666218

SOV1
Protein SOV1, mitochondrial

1

0

High-throughput

0.261

Low


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Last updated: 11Aug2025