HitPredict

Interactor 1: LTK (P29376)
Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1)
Gene: LTK

Interactor 2: DSG2 (Q14126)
Desmoglein-2 (Cadherin family member 5) (HDGC)
Gene: DSG2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 864 Hs			1 1118
+	Hs
		601509 FGFR2_HUMAN (163-833): 6.48e-137: 429: 20.03		DSG2_HUMAN (1-1118): 0: 1174: 100.00
+	Hs
		665396 EPHA3_HUMAN (388-798): 3.64e-124: 400: 27.30		DSG2_HUMAN (1-1118): 0: 1174: 100.00
+	Hs
		872440 EPHA5_HUMAN (389-809): 8.73e-124: 400: 26.02		DSG2_HUMAN (1-1118): 0: 1174: 100.00
+	Hs
		507992 FGFR1_HUMAN (333-827): 2.64e-122: 390: 24.42		DSG2_HUMAN (1-1118): 0: 1174: 100.00
+	Hs
		507929 FGFR1_HUMAN (333-827): 2.64e-122: 390: 24.42		CAD11_HUMAN (9-848): 0: 645: 22.22
+	Hs
		507817 FGFR1_HUMAN (333-827): 2.64e-122: 390: 24.42		CADH1_HUMAN (22-670): 0: 577: 31.67
+	Hs
		666577 LTK_HUMAN (1-864): 0: 763: 100.00		DSC2_HUMAN (28-494): 8.1e-51: 196: 16.90
+	Hs
		521744 EPHA2_HUMAN (446-813): 2.21e-109: 360: 30.38		CADH1_HUMAN (22-670): 0: 577: 31.67
+	Hs
		508294 FGFR1_HUMAN (333-827): 2.64e-122: 390: 24.42		PCDB7_HUMAN (54-599): 4.83e-92: 314: 19.42
+	Hs
		434134 RET_HUMAN (278-849): 5.71e-146: 461: 25.98		CADH2_HUMAN (1-489): 2.19e-63: 234: 18.52
+	Hs
		434321 RET_HUMAN (278-849): 5.71e-146: 461: 25.98		PCDGH_HUMAN (1-387): 8.41e-62: 230: 20.45
+	Hs
		435531 IGF1R_HUMAN (298-854): 3.35e-128: 419: 27.39		CADH2_HUMAN (1-489): 2.19e-63: 234: 18.52
+	Hs
		435534 IGF1R_HUMAN (298-854): 3.35e-128: 419: 27.39		CADH3_HUMAN (29-596): 2.57e-61: 227: 32.87
+	Hs
		507842 FGFR1_HUMAN (333-827): 2.64e-122: 390: 24.42		CADH2_HUMAN (1-489): 2.19e-63: 234: 18.52
+	Hs
		872427 EPHA5_HUMAN (389-809): 8.73e-124: 400: 26.02		DSC2_HUMAN (28-494): 8.1e-51: 196: 16.90
+	Hs
		665215 EPHA2_HUMAN (446-813): 2.21e-109: 360: 30.38		DSC2_HUMAN (28-494): 8.1e-51: 196: 16.90
+	Hs
		435643 IGF1R_HUMAN (298-854): 3.35e-128: 419: 27.39		DSC3_HUMAN (28-361): 8.23e-29: 126: 16.86
+	Hs
		411386 INSR_HUMAN (367-837): 3.2e-121: 400: 30.82		DSC3_HUMAN (28-361): 8.23e-29: 126: 16.86
+	Hs
		508000 FGFR1_HUMAN (333-827): 2.64e-122: 390: 24.42		DSC3_HUMAN (28-361): 8.23e-29: 126: 16.86
+	Hs
		537741 INSRR_HUMAN (391-827): 1.68e-110: 369: 34.69		DSC3_HUMAN (28-361): 8.23e-29: 126: 16.86