Interactor 1: CASP1 (P29466)
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
Gene: CASP1
Interactor 2: GSDMD (P57764)
Gasdermin-D (Gasdermin domain-containing protein 1) [Cleaved into: Gasdermin-D, N-terminal (GSDMD-NT) (hGSDMD-NTD); Gasdermin-D, C-terminal (GSDMD-CT) (hGSDMD-CTD); Gasdermin-D, p13 (Gasdermin-D, 13 kDa) (13 kDa GSDMD); Gasdermin-D, p40]
Gene: GSDMD
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.60 | 1.00 | 0.777 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 34296442 |
| Identification Methods | enzymatic study, pull down, protease assay |
| Interaction Type | direct interaction, protein cleavage, association, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Gasdermin_C~Peptidase_C14 |
| Common GO terms | GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0032731 - positive regulation of interleukin-1 beta production GO:0042742 - defense response to bacterium GO:0050729 - positive regulation of inflammatory response and 2 others more... |
| Homologous interactions | 3 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
