HitPredict

Interactor 1: CASP1 (P29466)
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
Gene: CASP1

Interactor 2: ASC (Q9ULZ3)
Apoptosis-associated speck-like protein containing a CARD (hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1)
Gene: PYCARD

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.978

The method score is based on:

Property Details
Experiments 26121674, 32435622, 30612879, 14634131, 16585594, 19337385, 11967258, 21385879, 24803432, 24630722, 25605870, 31421660, 34589402
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid, pull down, fluorescence microscopy, electron microscopy, fluorescence polarization spectroscopy, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CARD~CARD
Common GO terms GO:0002221 - pattern recognition receptor signaling pathway
GO:0005730 - nucleolus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005874 - microtubule
and 16 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 404
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024