Protein: RPC1
DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (DNA-directed RNA polymerase III subunit A) (RNA polymerase III 155 kDa subunit) (RPC155) (RNA polymerase III subunit C160)

Gene: RPC1, POLR3A
Organism: Homo sapiens
Interactions: 145
UniProt ID: O14802

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

165100

RPC2
DNA-directed RNA polymerase III subunit RPC2

7

20

Small-scale

0.954

High

165114

RPC10
DNA-directed RNA polymerase III subunit RPC10

6

20

High-throughput

0.940

High

165006

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

5

15

High-throughput

0.930

High

165028

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

5

10

High-throughput

0.927

High

164978

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

4

19

High-throughput

0.903

High

165081

RPC7L
DNA-directed RNA polymerase III subunit RPC7-like

4

1

High-throughput

0.900

High

165115

RPC8
DNA-directed RNA polymerase III subunit RPC8

4

12

High-throughput

0.895

High

165024

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

4

10

Small-scale

0.886

High

165088

MAF1
Repressor of RNA polymerase III transcription MAF1 homolog

3

1

High-throughput

0.861

High

164986

RPC9
DNA-directed RNA polymerase III subunit RPC9

3

4

High-throughput

0.847

High

164980

RPC7
DNA-directed RNA polymerase III subunit RPC7

2

1

Small-scale

0.789

High

165026

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

9

High-throughput

0.789

High

165005

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

19

High-throughput

0.754

High

165059

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

2

3

High-throughput

0.754

High

165099

RPC5
DNA-directed RNA polymerase III subunit RPC5

7

3

Small-scale

0.749

High

164998

RPC4
DNA-directed RNA polymerase III subunit RPC4

6

3

Small-scale

0.733

High

165000

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

2

11

High-throughput

0.712

High

165092

RPAP3
RNA polymerase II-associated protein 3

5

6

High-throughput

0.709

High

165031

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

4

8

High-throughput

0.702

High

165101

PIHD1
PIH1 domain-containing protein 1

4

3

High-throughput

0.694

High

165082

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

3

High-throughput

0.691

High

165089

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

1

High-throughput

0.691

High

165017

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

4

8

High-throughput

0.691

High

165033

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

4

11

High-throughput

0.691

High

165111

RUVB2
RuvB-like 2

4

9

High-throughput

0.691

High

165106

PFD2
Prefoldin subunit 2

4

3

High-throughput

0.683

High

165042

TEBP
Prostaglandin E synthase 3

3

1

High-throughput

0.667

High

165056

SKAP1
Src kinase-associated phosphoprotein 1

3

5

High-throughput

0.667

High

165103

UXT
Protein UXT

3

2

High-throughput

0.667

High

165112

RUVB1
RuvB-like 1

3

9

High-throughput

0.662

High

165095

GPN1
GPN-loop GTPase 1

3

9

High-throughput

0.650

High

164990

RMP
Unconventional prefoldin RPB5 interactor 1

3

3

Small-scale

0.640

High

165027

EVA1C
Protein eva-1 homolog C

3

0

High-throughput

0.638

High

165107

GPN3
GPN-loop GTPase 3

4

9

High-throughput

0.630

High

165015

CADH5
Cadherin-5

2

1

High-throughput

0.628

High

165091

ASB7
Ankyrin repeat and SOCS box protein 7

2

2

High-throughput

0.628

High

164982

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

8

High-throughput

0.618

High

164991

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

11

High-throughput

0.618

High

165012

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

11

High-throughput

0.618

High

165014

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

20

High-throughput

0.618

High

165018

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

20

High-throughput

0.618

High

165025

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

11

High-throughput

0.618

High

165032

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

12

High-throughput

0.618

High

165036

TF2B
Transcription initiation factor IIB

1

5

Small-scale

0.618

High

165087

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

3

High-throughput

0.618

High

165094

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

20

High-throughput

0.618

High

165102

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

20

High-throughput

0.618

High

165030

CH10
10 kDa heat shock protein, mitochondrial

2

1

High-throughput

0.584

High

165038

PSME1
Proteasome activator complex subunit 1

2

0

High-throughput

0.576

High

164993

MYC
Myc proto-oncogene protein

2

4

High-throughput

0.571

High

165079

PKP2
Plakophilin-2

1

2

Small-scale

0.561

High

165029

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

1

High-throughput

0.541

High

165037

EWS
RNA-binding protein EWS

1

5

High-throughput

0.541

High

165116

NEMO
NF-kappa-B essential modulator

1

1

High-throughput

0.541

High

64411

BDP1
Transcription factor TFIIIB component B'' homolog

1

4

High-throughput

0.536

High

164977

ML12B
Myosin regulatory light chain 12B

1

1

High-throughput

0.536

High

165007

CSK22
Casein kinase II subunit alpha'

1

12

High-throughput

0.536

High

165008

TBP
TATA-box-binding protein

1

4

High-throughput

0.536

High

165009

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

2

High-throughput

0.536

High

165010

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.536

High

165019

GRK6
G protein-coupled receptor kinase 6

1

2

High-throughput

0.536

High

165023

JAK3
Tyrosine-protein kinase JAK3

1

5

High-throughput

0.536

High

165034

CSK21
Casein kinase II subunit alpha

1

10

High-throughput

0.536

High

165039

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

High-throughput

0.536

High

165065

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

1

High-throughput

0.536

High

165067

TRI52
E3 ubiquitin-protein ligase TRIM52

1

2

High-throughput

0.536

High

165071

AURKB
Aurora kinase B

1

2

High-throughput

0.536

High

165076

PSKH2
Serine/threonine-protein kinase H2

1

1

High-throughput

0.536

High

165078

TESK2
Dual specificity testis-specific protein kinase 2

1

1

High-throughput

0.536

High

165074

DAA10
Dynein axonemal assembly factor 10

2

2

High-throughput

0.533

High

165105

ZNHI2
Zinc finger HIT domain-containing protein 2

1

1

High-throughput

0.515

High

128101

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

High-throughput

0.513

High

164983

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

High-throughput

0.513

High

164987

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.513

High

164995

FRIL
Ferritin light chain

1

0

High-throughput

0.513

High

164996

HG2A
HLA class II histocompatibility antigen gamma chain

1

0

High-throughput

0.513

High

165001

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.513

High

165003

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.513

High

165021

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

165051

KSR2
Kinase suppressor of Ras 2

1

0

High-throughput

0.513

High

165054

TRM1L
tRNA

1

0

High-throughput

0.513

High

165061

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.513

High

165063

NEK7
Serine/threonine-protein kinase Nek7

1

0

High-throughput

0.513

High

165072

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.513

High

165085

TSSK6
Testis-specific serine/threonine-protein kinase 6

1

0

High-throughput

0.513

High

165020

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

10

High-throughput

0.501

High

164979

PFD6
Prefoldin subunit 6

1

3

High-throughput

0.479

High

164981

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

3

High-throughput

0.479

High

164984

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

164985

BRD4
Bromodomain-containing protein 4

1

11

High-throughput

0.479

High

164988

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

5

High-throughput

0.479

High

164989

RECQ4
ATP-dependent DNA helicase Q4

1

11

High-throughput

0.479

High

164992

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

164997

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

165002

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

165004

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

165013

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

165016

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

165035

RAE1L
mRNA export factor RAE1

1

1

High-throughput

0.479

High

165040

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

165041

BRD3
Bromodomain-containing protein 3

1

11

High-throughput

0.479

High

165043

HABP4
Intracellular hyaluronan-binding protein 4

1

1

High-throughput

0.479

High

165045

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

10

High-throughput

0.479

High

165050

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

165053

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

165058

NUDC3
NudC domain-containing protein 3

1

1

High-throughput

0.479

High

165062

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

165064

ASB13
Ankyrin repeat and SOCS box protein 13

1

3

High-throughput

0.479

High

165073

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

165075

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

15

High-throughput

0.479

High

165077

CIC
Protein capicua homolog

1

2

High-throughput

0.479

High

165090

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

165093

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

165096

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

17

High-throughput

0.479

High

165097

PDRG1
p53 and DNA damage-regulated protein 1

1

2

High-throughput

0.479

High

165104

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

124142

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.458

High

165055

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

165070

S7A6O
Probable RNA polymerase II nuclear localization protein SLC7A6OS

1

0

High-throughput

0.458

High

165083

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.458

High

165084

MND1
Meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

165109

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.458

High

165113

2ABG
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

1

0

High-throughput

0.458

High

58758

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

1

High-throughput

0.445

High

164999

RPC22
Protein POLR1D, isoform 2

1

1

High-throughput

0.445

High

165022

IMA1
Importin subunit alpha-1

1

1

High-throughput

0.445

High

165048

S39A4
Zinc transporter ZIP4

1

4

High-throughput

0.445

High

165057

S13A5
Na(+)/citrate cotransporter

1

2

High-throughput

0.445

High

165066

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

2

High-throughput

0.445

High

165086

S39A8
Metal cation symporter ZIP8

1

4

High-throughput

0.445

High

165098

S39A9
Zinc transporter ZIP9

1

4

High-throughput

0.445

High

165047

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

2

High-throughput

0.437

High

165049

Q6PK50
HSP90AB1 protein

1

4

High-throughput

0.437

High

165069

Q96BE0
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.437

High

165080

Q9BPW0
Serine/threonine-protein phosphatase

1

10

High-throughput

0.437

High

165110

HECD1
E3 ubiquitin-protein ligase HECTD1

1

7

Small-scale

0.437

High

132896

S28A1
Sodium/nucleoside cotransporter 1

1

0

High-throughput

0.426

High

165011

RAE1
Rab proteins geranylgeranyltransferase component A 1

1

0

High-throughput

0.426

High

165044

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

165060

PALS1
Protein PALS1

1

0

High-throughput

0.426

High

165052

S39A5
Zinc transporter ZIP5

1

4

High-throughput

0.407

High

165108

S13A4
Solute carrier family 13 member 4

1

2

High-throughput

0.407

High

164994

RET4
Retinol-binding protein 4

1

0

High-throughput

0.279

Low

165046

CHIC1
Cysteine-rich hydrophobic domain-containing protein 1

1

0

High-throughput

0.279

Low

165068

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025