Interactor 1: NOS3 (P29474)
Nitric oxide synthase 3 (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (NOS type III) (NOSIII) (Nitric oxide synthase, endothelial) (Endothelial NOS) (eNOS)
Gene: NOS3

Interactor 2: NOS3 (P29474)
Nitric oxide synthase 3 (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (NOS type III) (NOSIII) (Nitric oxide synthase, endothelial) (Endothelial NOS) (eNOS)
Gene: NOS3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.89 1.00 0.948

The method score is based on:

Property Details
Experiments 8995432, 9115269, 11149895, 15721862, 10074942, 12437348, 18849972
Identification Methods pull down, two hybrid, biochemical, affinity chromatography technology, x-ray crystallography
Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains FAD_binding_1~FAD_binding_1, FAD_binding_1~Flavodoxin_1, FAD_binding_1~NAD_binding_1, Flavodoxin_1~Flavodoxin_1, Flavodoxin_1~NAD_binding_1, NAD_binding_1~NAD_binding_1, NO_synthase~NO_synthase
Common GO terms GO:0000139 - Golgi membrane
GO:0001525 - angiogenesis
GO:0001542 - ovulation from ovarian follicle
GO:0001701 - in utero embryonic development
GO:0001974 - blood vessel remodeling
and 62 others

more...

Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 1203
Hs

1 1203
+ Bt
+ Hs
+ Hs
+ Hs
+ Mm
+ Dm
+ Hs
+ Hs
+ Ec

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Last updated: 15 Jul 2024