Protein: CDK16
Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1)

Gene: CDK16
Organism: Homo sapiens
Interactions: 142
UniProt ID: Q00536

Gene Ontology (top 5):
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0004674 - protein serine/threonine kinase activity
GO:0004693 - cyclin-dependent protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1025567

CCYL1
Cyclin-Y-like protein 1

7

9

Small-scale

0.968

High

1025570

CCNY
Cyclin-Y

4

9

Small-scale

0.911

High

229322

ZBT14
Zinc finger and BTB domain-containing protein 14

3

1

High-throughput

0.871

High

881508

CDK8
Cyclin-dependent kinase 8

3

19

High-throughput

0.861

High

1025534

CDK17
Cyclin-dependent kinase 17

3

16

High-throughput

0.861

High

1025608

CILK1
Serine/threonine-protein kinase ICK

3

18

High-throughput

0.861

High

1025537

CDK18
Cyclin-dependent kinase 18

3

16

High-throughput

0.847

High

625315

CSK22
Casein kinase II subunit alpha'

2

19

High-throughput

0.811

High

667780

CDK2
Cyclin-dependent kinase 2

2

17

High-throughput

0.811

High

857312

CDN1B
Cyclin-dependent kinase inhibitor 1B

2

20

High-throughput

0.811

High

994988

CSK2B
Casein kinase II subunit beta

2

1

High-throughput

0.811

High

1025446

CDK5
Cyclin-dependent kinase 5

2

17

Small-scale

0.799

High

718884

CCND3
G1/S-specific cyclin-D3

2

20

High-throughput

0.783

High

375412

RASK
GTPase KRas

2

14

High-throughput

0.754

High

1025545

CD5R1
Cyclin-dependent kinase 5 activator 1

1

7

Small-scale

0.740

High

1025554

RHG21
Rho GTPase-activating protein 21

2

3

High-throughput

0.737

High

966197

1433G
14-3-3 protein gamma

5

20

Small-scale

0.720

High

798994

BRCA1
Breast cancer type 1 susceptibility protein

5

13

Small-scale

0.710

High

1025536

1433F
14-3-3 protein eta

4

20

Small-scale

0.701

High

971410

1433E
14-3-3 protein epsilon

4

10

High-throughput

0.699

High

729750

1433B
14-3-3 protein beta/alpha

4

20

High-throughput

0.697

High

990097

1433Z
14-3-3 protein zeta/delta

4

20

Small-scale

0.692

High

187338

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

1

High-throughput

0.691

High

997644

CSK21
Casein kinase II subunit alpha

1

19

High-throughput

0.691

High

1025591

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

16

High-throughput

0.691

High

1005350

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

4

Small-scale

0.647

High

66884

SPDE4
Speedy protein E4

1

17

High-throughput

0.618

High

176818

DCLK1
Serine/threonine-protein kinase DCLK1

1

7

High-throughput

0.618

High

230522

KIF1C
Kinesin-like protein KIF1C

1

4

High-throughput

0.618

High

241411

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.618

High

245218

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

11

High-throughput

0.618

High

373883

RASN
GTPase NRas

1

14

High-throughput

0.618

High

463455

LYN
Tyrosine-protein kinase Lyn

1

15

High-throughput

0.618

High

541439

FGFR1
Fibroblast growth factor receptor 1

1

19

High-throughput

0.618

High

710177

EPHA2
Ephrin type-A receptor 2

1

11

High-throughput

0.618

High

719212

MPIP2
M-phase inducer phosphatase 2

1

18

High-throughput

0.618

High

936299

AFAD
Afadin

1

10

High-throughput

0.618

High

956254

RAB2A
Ras-related protein Rab-2A

1

2

High-throughput

0.618

High

976207

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.618

High

977939

RHOB
Rho-related GTP-binding protein RhoB

1

11

High-throughput

0.618

High

1025539

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

2

High-throughput

0.618

High

1025542

MELK
Maternal embryonic leucine zipper kinase

1

2

High-throughput

0.618

High

1025543

ZN638
Zinc finger protein 638

1

6

High-throughput

0.618

High

1025544

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.618

High

1025546

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.618

High

1025548

RHOH
Rho-related GTP-binding protein RhoH

1

12

High-throughput

0.618

High

1025552

LARP7
La-related protein 7

1

19

High-throughput

0.618

High

1025555

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

10

High-throughput

0.618

High

1025561

PKHA7
Pleckstrin homology domain-containing family A member 7

1

15

High-throughput

0.618

High

1025565

PHLB2
Pleckstrin homology-like domain family B member 2

1

17

High-throughput

0.618

High

1025566

KSR1
Kinase suppressor of Ras 1

1

11

High-throughput

0.618

High

1025586

TESK2
Dual specificity testis-specific protein kinase 2

1

12

High-throughput

0.618

High

1025592

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.618

High

1025594

PKHA5
Pleckstrin homology domain-containing family A member 5

1

10

High-throughput

0.618

High

1025596

KI13B
Kinesin-like protein KIF13B

1

4

High-throughput

0.618

High

1025605

ZBT21
Zinc finger and BTB domain-containing protein 21

1

3

High-throughput

0.618

High

1025606

PPM1H
Protein phosphatase 1H

1

5

High-throughput

0.618

High

1025609

GAB2
GRB2-associated-binding protein 2

1

5

High-throughput

0.618

High

690907

1433T
14-3-3 protein theta

2

20

Small-scale

0.614

High

1025558

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

2

6

High-throughput

0.611

High

1025582

SNX27
Sorting nexin-27

2

3

High-throughput

0.611

High

1025590

MCMBP
Mini-chromosome maintenance complex-binding protein

2

0

High-throughput

0.602

High

296982

CCNK
Cyclin-K

1

20

Small-scale

0.590

High

856641

BAG6
Large proline-rich protein BAG6

1

10

High-throughput

0.590

High

1025541

CCNI
Cyclin-I

1

20

Small-scale

0.590

High

1025553

SPDYA
Speedy protein A

1

17

Small-scale

0.590

High

1025589

RTKN
Rhotekin

1

0

High-throughput

0.586

High

1025600

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.586

High

1025578

APBP2
Amyloid protein-binding protein 2

1

4

High-throughput

0.573

High

1025580

SH3K1
SH3 domain-containing kinase-binding protein 1

2

2

High-throughput

0.571

High

1025559

AN34A
Ankyrin repeat domain-containing protein 34A

1

2

High-throughput

0.553

High

1025577

SRS12
Serine/arginine-rich splicing factor 12

1

5

High-throughput

0.553

High

1025607

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

1

High-throughput

0.553

High

573065

KPYM
Pyruvate kinase PKM

1

3

High-throughput

0.536

High

750560

CP2CI
Cytochrome P450 2C18

1

2

High-throughput

0.536

High

770379

T2FA
General transcription factor IIF subunit 1

1

2

High-throughput

0.536

High

977463

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

10

High-throughput

0.536

High

991011

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

6

High-throughput

0.536

High

1025593

I20L2
Interferon-stimulated 20 kDa exonuclease-like 2

1

1

High-throughput

0.536

High

1025611

SGT1
Protein SGT1 homolog

1

3

High-throughput

0.536

High

1025547

SC23A
Protein transport protein Sec23A

1

5

Small-scale

0.529

High

421934

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

1025571

PJA1
E3 ubiquitin-protein ligase Praja-1

1

3

Small-scale

0.501

High

1025595

RC3H2
Roquin-2

1

5

High-throughput

0.489

High

954946

S10AA
Protein S100-A10

1

13

Small-scale

0.481

High

1025576

ATRIP
ATR-interacting protein

1

1

High-throughput

0.481

High

172703

XPO1
Exportin-1

1

4

High-throughput

0.479

High

208653

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

3

High-throughput

0.479

High

252045

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

2

High-throughput

0.479

High

269540

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

4

High-throughput

0.479

High

281307

GGYF1
GRB10-interacting GYF protein 1

1

3

High-throughput

0.479

High

324796

HEXI1
Protein HEXIM1

1

8

High-throughput

0.479

High

385656

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

9

High-throughput

0.479

High

488000

DPOLA
DNA polymerase alpha catalytic subunit

1

7

High-throughput

0.479

High

540403

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

637884

NF1
Neurofibromin

1

4

High-throughput

0.479

High

695227

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

715539

MARCS
Myristoylated alanine-rich C-kinase substrate

1

8

High-throughput

0.479

High

730513

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

940918

HDAC4
Histone deacetylase 4

1

5

High-throughput

0.479

High

974985

ARF6
ADP-ribosylation factor 6

1

4

High-throughput

0.479

High

1025538

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

3

High-throughput

0.479

High

1025540

CUL3
Cullin-3

1

6

High-throughput

0.479

High

1025549

ZYX
Zyxin

1

1

High-throughput

0.479

High

1025556

SPD2A
SH3 and PX domain-containing protein 2A

1

1

High-throughput

0.479

High

1025557

DEN4C
DENN domain-containing protein 4C

1

1

High-throughput

0.479

High

1025560

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

1025569

SERB1
SERPINE1 mRNA-binding protein 1

1

10

High-throughput

0.479

High

1025573

F110B
Protein FAM110B

1

1

High-throughput

0.479

High

1025574

DEN1A
DENN domain-containing protein 1A

1

2

High-throughput

0.479

High

1025581

EDC3
Enhancer of mRNA-decapping protein 3

1

1

High-throughput

0.479

High

1025583

SCLT1
Sodium channel and clathrin linker 1

1

20

High-throughput

0.479

High

1025584

RAB3I
Rab-3A-interacting protein

1

1

High-throughput

0.479

High

1025585

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

5

High-throughput

0.479

High

1025587

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

High-throughput

0.479

High

1025588

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

1025601

CING
Cingulin

1

13

High-throughput

0.479

High

1025602

LIMA1
LIM domain and actin-binding protein 1

1

4

High-throughput

0.479

High

1025603

NGAP
Ras GTPase-activating protein nGAP

1

5

High-throughput

0.479

High

1025604

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

5

High-throughput

0.479

High

1025610

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.479

High

1025612

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

1025613

KCTD3
BTB/POZ domain-containing protein KCTD3

1

7

High-throughput

0.479

High

339071

NADK
NAD kinase

1

0

High-throughput

0.458

High

1025598

FA53C
Protein FAM53C

1

0

High-throughput

0.458

High

1025599

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.458

High

72410

MI4GD
MIF4G domain-containing protein

1

3

Small-scale

0.457

High

319091

SC24D
Protein transport protein Sec24D

1

7

Small-scale

0.457

High

1025550

UAP1
UDP-N-acetylhexosamine pyrophosphorylase

1

4

Small-scale

0.457

High

630248

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

2

High-throughput

0.445

High

1025535

PTPS
6-pyruvoyl tetrahydrobiopterin synthase

1

0

Small-scale

0.438

High

767970

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

1025551

TBC25
TBC1 domain family member 25

1

3

High-throughput

0.437

High

1025563

SYDE1
Rho GTPase-activating protein SYDE1

1

6

High-throughput

0.437

High

1025597

FBX8
F-box only protein 8

1

1

Small-scale

0.417

High

1025572

RDH11
Retinol dehydrogenase 11

1

3

High-throughput

0.407

High

1025564

NUP54
Nucleoporin p54

2

0

High-throughput

0.328

High

1025575

DEP1B
DEP domain-containing protein 1B

1

0

High-throughput

0.249

Low

1025579

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

1025562

CF20D
Protein CFAP20DC

1

0

Small-scale

0.238

Low

1025568

TMM99
Uncharacterized protein KRT10-AS1

1

0

Small-scale

0.238

Low

62486

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025