HitPredict

Interactor 1: TYK2 (P29597)
Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)
Gene: TYK2

Interactor 2: STAT2 (P52630)
Signal transducer and activator of transcription 2 (p113)
Gene: STAT2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.789

The method score is based on:

Property Details
Experiments 32953130, 34521819
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007259 - cell surface receptor signaling pathway via JAK-STAT
GO:0060337 - type I interferon-mediated signaling pathway
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1187
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024