HitPredict

Interactor 1: MARCS (P29966)
Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL)
Gene: MARCKS

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	EF-hand_7~MARCKS
Common GO terms	GO:0005516 - calmodulin binding GO:0005886 - plasma membrane GO:0051015 - actin filament binding GO:0070062 - extracellular exosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 332 Hs			1 2472
+	Hs
		164571 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		297814 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		K0754_HUMAN (1-1482): 9.32e-58: 225: 14.65
+	Hs
		669987 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		521586 TITIN_HUMAN (1-308): 6.95e-09: 59.4: 10.71		ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25
+	Hs
		211629 TITIN_HUMAN (1-308): 6.95e-09: 59.4: 10.71		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15