Protein: FBX50
F-box only protein 50 (NCC receptor protein 1 homolog) (NCCRP-1) (Non-specific cytotoxic cell receptor protein 1 homolog)

Gene: FBX50, NCCRP1
Organism: Homo sapiens
Interactions: 131
UniProt ID: Q6ZVX7

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006516 - glycoprotein catabolic process
GO:0008284 - positive regulation of cell population proliferation
GO:0019005 - SCF ubiquitin ligase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

943851

CF298
Cilia- and flagella-associated protein 298

3

0

High-throughput

0.638

High

1156024

ZIC1
Zinc finger protein ZIC 1

2

1

High-throughput

0.628

High

1256977

CDK15
Cyclin-dependent kinase 15

2

1

High-throughput

0.628

High

1256967

FBXW7
F-box/WD repeat-containing protein 7

1

2

Small-scale

0.618

High

830953

CCNF
Cyclin-F

1

0

High-throughput

0.586

High

1137799

TNIP1
TNFAIP3-interacting protein 1

2

3

High-throughput

0.584

High

537386

HSP7C
Heat shock cognate 71 kDa protein

2

2

High-throughput

0.571

High

1125805

GPR18
N-arachidonyl glycine receptor

2

2

High-throughput

0.558

High

213953

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

High-throughput

0.536

High

352713

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

1

High-throughput

0.536

High

396380

ESR1
Estrogen receptor

1

1

High-throughput

0.536

High

456111

FES
Tyrosine-protein kinase Fes/Fps

1

1

High-throughput

0.536

High

703630

MK01
Mitogen-activated protein kinase 1

1

1

High-throughput

0.536

High

722793

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

1

High-throughput

0.536

High

733382

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

1217960

MYOME
Myomegalin

1

2

High-throughput

0.536

High

1256969

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

3

High-throughput

0.536

High

563965

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

132614

UPK1A
Uroplakin-1a

1

0

High-throughput

0.513

High

185204

FANCG
Fanconi anemia group G protein

1

0

High-throughput

0.513

High

194471

P2RX6
P2X purinoceptor 6

1

0

High-throughput

0.513

High

291822

STK16
Serine/threonine-protein kinase 16

1

0

High-throughput

0.513

High

292664

RENR
Renin receptor

1

0

High-throughput

0.513

High

391628

FRIH
Ferritin heavy chain

1

0

High-throughput

0.513

High

541033

PIM1
Serine/threonine-protein kinase pim-1

1

0

High-throughput

0.513

High

602807

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

725789

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.513

High

943078

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

983669

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.513

High

1023815

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

1136455

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.513

High

1157529

PKN2
Serine/threonine-protein kinase N2

1

0

High-throughput

0.513

High

1256951

APTX
Aprataxin

1

0

High-throughput

0.513

High

1256955

AROS
Active regulator of SIRT1

1

0

High-throughput

0.513

High

1256957

YAF2
YY1-associated factor 2

1

0

High-throughput

0.513

High

1256972

RM38
Large ribosomal subunit protein mL38

1

0

High-throughput

0.513

High

1256985

5NT1A
Cytosolic 5'-nucleotidase 1A

1

0

High-throughput

0.513

High

1256986

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.513

High

1256990

DUS21
Dual specificity protein phosphatase 21

1

0

High-throughput

0.513

High

1256994

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

1257004

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.513

High

552287

ADT3
ADP/ATP translocase 3

1

6

High-throughput

0.489

High

622828

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

5

High-throughput

0.489

High

939017

UCP2
Dicarboxylate carrier SLC25A8

1

9

High-throughput

0.489

High

1256963

ZDH19
Palmitoyltransferase ZDHHC19

1

1

High-throughput

0.489

High

1256968

PIGT
GPI-anchor transamidase component PIGT

1

2

High-throughput

0.489

High

1256982

SH23A
SH2 domain-containing protein 3A

1

2

High-throughput

0.489

High

1256992

ZDHC6
Palmitoyltransferase ZDHHC6

1

1

High-throughput

0.489

High

342928

HERC2
E3 ubiquitin-protein ligase HERC2

1

1

High-throughput

0.479

High

485221

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

3

High-throughput

0.479

High

623402

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

888144

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

983855

RBX1
E3 ubiquitin-protein ligase RBX1

1

5

Small-scale

0.479

High

986515

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

1118071

DX39B
Spliceosome RNA helicase DDX39B

1

7

High-throughput

0.479

High

1256964

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

High-throughput

0.479

High

1256988

DDX24
ATP-dependent RNA helicase DDX24

1

5

High-throughput

0.479

High

1256999

PD1L1
Programmed cell death 1 ligand 1

1

12

High-throughput

0.479

High

1257001

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1256961

MCPH1
Microcephalin

1

0

Small-scale

0.460

High

225618

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

0

High-throughput

0.458

High

293903

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

372377

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

374013

RASN
GTPase NRas

1

0

High-throughput

0.458

High

872458

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

1246850

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1256979

RANB9
Ran-binding protein 9

1

0

Small-scale

0.458

High

1256987

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

1256993

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

554233

BMP4
Bone morphogenetic protein 4

1

7

High-throughput

0.445

High

839470

PI4KA
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.445

High

1209301

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

1226926

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.445

High

1256973

ASB9
Ankyrin repeat and SOCS box protein 9

1

1

High-throughput

0.445

High

1257000

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

1

High-throughput

0.445

High

106153

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

1195657

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.437

High

1256958

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.437

High

1256965

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

1256998

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

7

High-throughput

0.437

High

406976

THY1
Thy-1 membrane glycoprotein

1

0

High-throughput

0.426

High

650556

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

0

High-throughput

0.426

High

839573

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.426

High

1093131

STK4
Serine/threonine-protein kinase 4

1

0

High-throughput

0.426

High

1116667

RIN1
Ras and Rab interactor 1

1

0

High-throughput

0.426

High

1129827

EPN4
Clathrin interactor 1

1

0

High-throughput

0.426

High

1256980

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.426

High

276216

LRRN2
Leucine-rich repeat neuronal protein 2

1

11

High-throughput

0.407

High

1043632

COAA1

1

6

High-throughput

0.407

High

1256959

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

2

High-throughput

0.407

High

1256966

WNT2B
Protein Wnt-2b

1

2

Small-scale

0.407

High

1256991

SG196
Protein O-mannose kinase

1

1

High-throughput

0.407

High

1257003

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

9

High-throughput

0.407

High

1256974

MITOK
Mitochondrial potassium channel

3

0

High-throughput

0.347

High

1257005

FCF1
rRNA-processing protein FCF1 homolog

2

0

High-throughput

0.328

High

1256962

DDI1
Protein DDI1 homolog 1

2

0

High-throughput

0.316

High

1256954

ZC3C1
Zinc finger C3HC-type protein 1

2

0

High-throughput

0.313

High

135811

RTCA
RNA 3'-terminal phosphate cyclase

1

0

High-throughput

0.279

Low

255086

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.279

Low

282737

E2F6
Transcription factor E2F6

1

0

High-throughput

0.279

Low

666855

CCNC
Cyclin-C

1

0

High-throughput

0.279

Low

876353

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

1055614

GABPA
GA-binding protein alpha chain

1

0

High-throughput

0.279

Low

1181317

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

1205113

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.279

Low

1234427

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.279

Low

1249535

AMTN
Amelotin

1

0

High-throughput

0.279

Low

1256950

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.279

Low

1256953

BPHL
Serine hydrolase BPHL

1

0

High-throughput

0.279

Low

1256956

S35F2
Solute carrier family 35 member F2

1

0

High-throughput

0.279

Low

1256960

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.279

Low

1256970

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

1256976

CABS1
Calcium-binding and spermatid-specific protein 1

1

0

High-throughput

0.279

Low

1256978

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.279

Low

1256981

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.279

Low

1256983

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.279

Low

1256995

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.279

Low

1256996

TB22B
TBC1 domain family member 22B

1

0

High-throughput

0.279

Low

1256997

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.279

Low

1257002

PHF11
PHD finger protein 11

1

0

High-throughput

0.279

Low

1256971

PKHB2
Pleckstrin homology domain-containing family B member 2

1

0

High-throughput

0.249

Low

1256989

RNF38
E3 ubiquitin-protein ligase RNF38

1

0

Small-scale

0.249

Low

87492

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

213416

ZSC12
Zinc finger and SCAN domain-containing protein 12

1

0

High-throughput

0.232

Low

261205

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low

505290

F153B
Protein FAM153B

1

0

High-throughput

0.232

Low

1231623

RL7L
Ribosomal protein uL30-like

1

0

High-throughput

0.232

Low

1253194

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low

1256952

RM10
Large ribosomal subunit protein uL10m

1

0

High-throughput

0.232

Low

1256975

MRAP2
Melanocortin-2 receptor accessory protein 2

1

0

High-throughput

0.232

Low

1256984

RSRP1
Arginine/serine-rich protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025