HitPredict

Interactor 1: PRDX3 (P30048)
Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) (Thioredoxin-dependent peroxiredoxin 3)
Gene: PRDX3

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	21182203
Identification Methods	affinity chromatography technology
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005739 - mitochondrion GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 256 Hs			1 530
+	Hs
		1026738 PRDX4_HUMAN (35-255): 3.38e-103: 302: 58.82		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369052 PRDX3_HUMAN (1-256): 3.48e-122: 349: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		685741 PRDX2_HUMAN (58-255): 2.07e-104: 302: 63.13		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369073 PRDX2_HUMAN (58-255): 2.07e-104: 302: 63.13		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369520 PRDX4_HUMAN (35-255): 3.38e-103: 302: 58.82		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		377120 PRDX3_HUMAN (1-256): 3.48e-122: 349: 100.00		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		670745 PRDX6_HUMAN (63-254): 3.4e-68: 211: 25.25		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369049 PRDX6_HUMAN (63-254): 3.4e-68: 211: 25.25		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		611429 PRDX4_HUMAN (35-255): 3.38e-103: 302: 58.82		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Rn
		415149 PRDX1_RAT (63-253): 5.84e-101: 293: 63.02		GCR_RAT (3-495): 5.89e-100: 321: 23.03
+	Hs
		487909 PRDX6_HUMAN (63-254): 3.4e-68: 211: 25.25		RARA_HUMAN (52-505): 3.54e-105: 324: 23.74
+	Hs
		611378 PRDX6_HUMAN (63-254): 3.4e-68: 211: 25.25		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		670707 PRDX6_HUMAN (63-254): 3.4e-68: 211: 25.25		HNF4G_HUMAN (148-520): 5.7e-102: 314: 24.40
+	Hs
		414494 PRDX1_HUMAN (63-253): 1.5e-100: 293: 63.54		PRGR_HUMAN (149-459): 2.26e-41: 161: 32.82
+	Hs
		487392 PRDX4_HUMAN (35-255): 3.38e-103: 302: 58.82		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487366 PRDX1_HUMAN (63-253): 1.5e-100: 293: 63.54		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59