HitPredict

Interactor 1: 2AAA (P30153)
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)
Gene: PPP2R1A

Interactor 2: PP4C (P60510)
Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) (Protein phosphatase X) (PP-X)
Gene: PPP4C

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.956

Property	Details
Experiments	28330616, 33961781, 19156129, 27880917, 17353931, 18715871
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HEAT~Metallophos, HEAT_2~Metallophos
Common GO terms	GO:0004722 - protein serine/threonine phosphatase activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 589 Hs			1 307
+	Mm
		915332 2AAA_MOUSE (1-589): 2.29e-166: 488: 99.83		PP2AB_MOUSE (6-307): 0: 523: 65.23
+	Hs
		672072 2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00		PP2AB_HUMAN (6-307): 0: 523: 65.23
+	Mm
		930638 2AAA_MOUSE (1-589): 2.29e-166: 488: 99.83		PP2AA_MOUSE (6-307): 0: 522: 65.89
+	Hs
		672079 2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00		PP2AA_HUMAN (6-307): 0: 522: 65.89
+	Hs
		672395 2AAB_HUMAN (9-589): 7.23e-158: 466: 86.40		PP4C_HUMAN (1-307): 0: 536: 100.00
+	Hs
		87319 C9J9C1_HUMAN (1-589): 1.06e-161: 477: 93.48		PP2AB_HUMAN (6-307): 0: 523: 65.23
+	Hs
		87320 C9J9C1_HUMAN (1-589): 1.06e-161: 477: 93.48		PP2AA_HUMAN (6-307): 0: 522: 65.89
+	Hs
		672399 2AAB_HUMAN (9-589): 7.23e-158: 466: 86.40		PP2AB_HUMAN (6-307): 0: 523: 65.23
+	Hs
		672402 2AAB_HUMAN (9-589): 7.23e-158: 466: 86.40		PP2AA_HUMAN (6-307): 0: 522: 65.89
+	Dm
		619857 2AAA_DROME (1-578): 2.84e-146: 436: 75.35		PP2A_DROME (2-307): 0: 522: 64.05
+	Mm
		956531 PP4R4_MOUSE (25-487): 9.85e-38: 151: 17.39		PP4C_MOUSE (1-307): 0: 536: 100.00
+	Hs
		268640 SF3B1_HUMAN (12-589): 2.5e-28: 122: 13.20		PP4C_HUMAN (1-307): 0: 536: 100.00
+	Hs
		268648 SF3B1_HUMAN (12-589): 2.5e-28: 122: 13.20		PP1A_HUMAN (2-304): 0: 517: 43.89
+	Sp
		619320 2AAA_SCHPO (5-393): 1.82e-31: 131: 21.41		PP2A2_SCHPO (2-307): 0: 507: 63.40
+	Hs
		890979 PP4R4_HUMAN (13-411): 1.42e-12: 72.9: 16.71		PP4C_HUMAN (1-307): 0: 536: 100.00
+	Bt
		61642 F1MRS1_BOVIN (325-583): 5.72e-09: 61.2: 17.04		PP4C_BOVIN (1-307): 0: 536: 100.00
+	Hs
		890987 PP4R1_HUMAN (325-583): 8.14e-09: 60.9: 17.78		PP4C_HUMAN (1-307): 0: 536: 100.00
+	Sp
		619310 2AAA_SCHPO (5-393): 1.82e-31: 131: 21.41		PP2A1_SCHPO (2-307): 3.56e-154: 435: 63.19
+	Hs
		135476 GCN1_HUMAN (28-589): 5.37e-25: 112: 16.01		PPP6_HUMAN (6-307): 1.53e-148: 420: 61.92
+	Sc
		618757 2AAA_YEAST (13-235): 9.24e-13: 72.9: 23.18		PP2A1_YEAST (4-307): 1.5e-148: 423: 60.98